A Study to Describe the Safety and Effectiveness of Venetoclax in Acute Myeloid Leukemia (AML) Patients (REVIVE Study)

NCT ID: NCT03987958

Last Updated: 2026-01-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-08-08

Study Completion Date

2027-07-31

Brief Summary

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This study will describe the safety and effectiveness of venetoclax in AML patients in routine clinical practice in Israel. The decision to treat with venetoclax is made by the physician prior to any decision regarding participation in this study.

Detailed Description

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Conditions

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Acute Myeloid Leukemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Venetoclax

Participants in this observational study will receive treatment with venetoclax for AML.

The decision to treat with venetoclax has been made independently from this observational study before participants are offered the opportunity to participate in this study.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Participant diagnosed with Acute Myeloid Leukemia (AML) and is eligible to receive venetoclax per Israel Ministry of Health.
* Participant who will be treated with venetoclax and the decision to treat with venetoclax is made by the physician prior to any decision regarding participation in this study.

Exclusion Criteria

\- Participant participating in an interventional trial within 30 days prior to starting venetoclax treatment.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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Meir Medical Center /ID# 213352

Kfar Saba, Central District, Israel

Site Status

Assuta Tel Aviv Medical Center /ID# 213371

Tel Aviv, Central District, Israel

Site Status

HaEmek Medical Center /ID# 213370

Afula, Haifa District, Israel

Site Status

Shaare Zedek Medical Center /ID# 228016

Jerusalem, Jerusalem, Israel

Site Status

Hadassah /ID# 213356

Jerusalem, Jerusalem, Israel

Site Status

ZIV Medical Center /ID# 229211

Safed, Northern District, Israel

Site Status

Soroka University Medical Center /ID# 213369

Beersheba, Southern District, Israel

Site Status

The Chaim Sheba Medical Center /ID# 213353

Ramat Gan, Tel Aviv, Israel

Site Status

Tel Aviv Sourasky Medical Center /ID# 213354

Tel Aviv, Tel Aviv, Israel

Site Status

Rambam Health Care Campus /ID# 213355

Haifa, , Israel

Site Status

Bnai Zion Medical Center /ID# 213344

Haifa, , Israel

Site Status

Rabin Medical Center. /ID# 213343

Petah Tikva, , Israel

Site Status

Countries

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Israel

References

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Wolach O, Levi I, Nachmias B, Tavor S, Amitai I, Ofran Y, Ganzel C, Zuckerman T, Okasha D, Hellmann I, Tadmor T, Dally N, Canaani J, Stemer G, Grunspan M, Berger AJ, Frankel N, Berelovich J, Bleterman A, Barak M, Cohen R, Moshe Y. Trial eligibility, treatment patterns, and outcome for venetoclax-based therapy in AML: a prospective cohort study. Blood Adv. 2025 Apr 8;9(7):1544-1554. doi: 10.1182/bloodadvances.2024014014.

Reference Type DERIVED
PMID: 39637307 (View on PubMed)

Related Links

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Other Identifiers

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P19-831

Identifier Type: -

Identifier Source: org_study_id

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