An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

NCT ID: NCT03844048

Last Updated: 2025-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

165 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-06

Study Completion Date

2026-02-28

Brief Summary

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The purpose of this extension study is to provide venetoclax and obtain long-term safety data for subjects who continue to tolerate and derive benefit from receiving venetoclax in ongoing studies.

Detailed Description

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Conditions

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Chronic Lymphocytic Leukemia Acute Myeloid Leukemia Multiple Myeloma Non-Hodgkin's Lymphoma Acute Lymphoblastic Leukemia Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Venetoclax

Venetoclax at the same dose administered to each subject during the previous study in which they were enrolled.

Group Type EXPERIMENTAL

Venetoclax

Intervention Type DRUG

oral; film-coated tablets or tablets for oral suspension

Interventions

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Venetoclax

oral; film-coated tablets or tablets for oral suspension

Intervention Type DRUG

Other Intervention Names

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ABT-199 Venclexta

Eligibility Criteria

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Inclusion Criteria

* Subject has been enrolled and dosed in an ongoing venetoclax study and continues to tolerate and derive benefit from the study drug.
* Male subject agrees to refrain from sperm donation.
* Female subjects must not be pregnant or breastfeeding.

Exclusion Criteria

\- None.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AbbVie

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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ABBVIE INC.

Role: STUDY_DIRECTOR

AbbVie

Locations

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University of Arizona Cancer Center - Tucson /ID# 210548

Tucson, Arizona, United States

Site Status

UCLA Santa Monica Hematology Oncology /ID# 210551

Los Angeles, California, United States

Site Status

Ingalls Memorial Hosp /ID# 210553

Harvey, Illinois, United States

Site Status

Dana-Farber Cancer Institute /ID# 215360

Boston, Massachusetts, United States

Site Status

University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 231132

Ann Arbor, Michigan, United States

Site Status

Dartmouth-Hitchcock Medical Center /ID# 210555

Lebanon, New Hampshire, United States

Site Status

Swedish Cancer Institute /ID# 213120

Seattle, Washington, United States

Site Status

Royal Prince Alfred Hospital /ID# 239557

Camperdown, New South Wales, Australia

Site Status

St George Hospital /ID# 225589

Kogarah, New South Wales, Australia

Site Status

Liverpool Hospital /ID# 225591

Liverpool, New South Wales, Australia

Site Status

Peter MacCallum Cancer Ctr /ID# 210559

Melbourne, Victoria, Australia

Site Status

Fiona Stanley Hospital /ID# 239480

Murdoch, Western Australia, Australia

Site Status

Perth Blood Institute Ltd /ID# 225592

Nedlands, Western Australia, Australia

Site Status

Duplicate_Medizinische Universitaet Graz /ID# 223817

Graz, Styria, Austria

Site Status

Cliniques Universitaires UCL Saint-Luc /ID# 224327

Brussels, Brussels Capital, Belgium

Site Status

CHUQ- Hôpital de l'Enfant-Jesus /ID# 224616

Québec, Quebec, Canada

Site Status

Rigshospitalet /ID# 224213

Copenhagen Ø, Capital Region, Denmark

Site Status

Aarhus Universitetshospital - Skejby /ID# 224214

Aarhus, Central Jutland, Denmark

Site Status

CHU Grenoble - Hopital Michallon /ID# 240497

La Tronche, Isere, France

Site Status

HCL - Hopital Lyon Sud /ID# 213508

Pierre-Bénite, Rhone, France

Site Status

General Hospital of Athens Laiko /ID# 224087

Athens, Attica, Greece

Site Status

General Hospital of Thessaloniki George Papanikolaou /ID# 224088

Thessaloniki, , Greece

Site Status

Queen Mary Hospital /ID# 224944

Hong Kong, , Hong Kong

Site Status

Beaumont Hospital /ID# 225165

Dublin, , Ireland

Site Status

Kobe City Medical Center General Hospital /ID# 241518

Kobe, Hyōgo, Japan

Site Status

Duplicate_National Hospital Organization Mito Medical Center /ID# 241986

Higashi Ibaraki-gun, Ibaraki, Japan

Site Status

Okayama Medical Center /ID# 241517

Okayama, Okayama-ken, Japan

Site Status

National Cancer Center Hospital /ID# 241516

Chuo-ku, Tokyo, Japan

Site Status

Centro de Investigacion Clínica Chapultepec SA de CV /ID# 227018

Morelia, Michoacán, Mexico

Site Status

Hospital Universitario Dr. Jose Eleuterio Gonzalez /ID# 227017

Monterrey, Nuevo León, Mexico

Site Status

Aotearoa Clinical Trials /ID# 225596

Papatoetoe, Auckland, New Zealand

Site Status

North Shore Hospital /ID# 225597

Takapuna, Auckland, New Zealand

Site Status

Wellington Regional Hospital /ID# 225593

Newtown, Wellington Region, New Zealand

Site Status

Duplicate_Pratia MCM Krakow /ID# 218561

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Instytut Hematologii i Transfuzjologii /ID# 225478

Warsaw, Masovian Voivodeship, Poland

Site Status

SP ZOZ Zespol Szpitali Miejskich w Chorzowie /ID# 225474

Chorzów, Silesian Voivodeship, Poland

Site Status

IPO Lisboa FG, EPE /ID# 225072

Lisbon, , Portugal

Site Status

Federal State Budgetary Scientific Institution N.N. Blokhin /ID# 225194

Moscow, Moscow, Russia

Site Status

Regional Oncological Dispensary /ID# 225195

Penza, Penza Oblast, Russia

Site Status

Samsung Medical Center /ID# 240882

Seoul, Seoul Teugbyeolsi, South Korea

Site Status

Hospital Universitario Fundacion Jimenez Diaz /ID# 225476

Madrid, , Spain

Site Status

Duplicate_Skane University Hospital Lund /ID# 224747

Lund, Skåne County, Sweden

Site Status

National Taiwan University Hospital /ID# 224946

Taipei City, Taipei, Taiwan

Site Status

China Medical University Hospital /ID# 224945

Taichung, , Taiwan

Site Status

Ankara Univ Medical Faculty /ID# 225043

Ankara, , Turkey (Türkiye)

Site Status

Istanbul University Istanbul Medical Faculty /ID# 225045

Istanbul, , Turkey (Türkiye)

Site Status

Vehbi Koc vakfi Amerikan Hasta /ID# 225046

Istanbul, , Turkey (Türkiye)

Site Status

Municipal Non-Profit Enterprise City Clinical Hospital 4 of Dnipro City Council /ID# 240575

Dnipro, , Ukraine

Site Status

Derriford Hospital and the Royal Eye Infirmary /ID# 218731

Plymouth, Devon, United Kingdom

Site Status

Leicester Royal Infirmary /ID# 240468

Leicester, England, United Kingdom

Site Status

University College London Hospital /ID# 240467

London, Greater London, United Kingdom

Site Status

University Hospital Southampton NHS Foundation Trust /ID# 225161

Southampton, Hampshire, United Kingdom

Site Status

Blackpool Teaching Hospitals NHS Foundation Trust /ID# 225163

Blackpool, , United Kingdom

Site Status

Clatterbridge Cancer Centre - Liverpool /ID# 218736

Liverpool, , United Kingdom

Site Status

King's College Hospital NHS Foundation Trust /ID# 218735

London, , United Kingdom

Site Status

The Royal Wolverhampton NHS Trust /ID# 225164

Wolverhampton, , United Kingdom

Site Status

Countries

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United States Australia Austria Belgium Canada Denmark France Greece Hong Kong Ireland Japan Mexico New Zealand Poland Portugal Russia South Korea Spain Sweden Taiwan Turkey (Türkiye) Ukraine United Kingdom

Related Links

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Other Identifiers

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2022-501522-38-00

Identifier Type: OTHER

Identifier Source: secondary_id

M19-388

Identifier Type: -

Identifier Source: org_study_id

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