TQLB for Postoperative Pain After Laparoscopic Partial Nephrectomy

NCT ID: NCT03982784

Last Updated: 2019-11-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-06-10
• Study Completion Date: 2019-11-10

Brief Summary

This prospective, randomized study,control study aims to compare the analgesic effect,opioids consumption,quality of recovery,length of hospital stay，et al. between single-injection QLB(quadratus lumborum block)+ intravenous patient-controlled analgesia (IPCA) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing laparoscopic partial nephrectomy.

Conditions

Laparoscopic Renal Surgery; Pain Management; Nerve Block

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: DOUBLE

Study Groups

single-injection TQLB(transmuscular quadratus lumborum block)

Single-injection of TQLB is given preoperatively + postoperative IPCA(intravenous patient controlled analgesia)

Group Type: EXPERIMENTAL

single-injection TQLB(transmuscular quadratus lumborum block)

Intervention Type: PROCEDURE

Inject 0.6ml/kg local anesthetics in between quadratus lumborum and psoas major under ultrasound guidance

Morphine given as IPCA(intravenous patient controlled analgesia)

Intervention Type: DRUG

PCIA was initiated using a pump set to deliver boluses of 1.5-2 mg of morphine with a 5-minute lockout interval and no background infusion. The maximal permitted dosage of morphine was set at 8 mg/h.

Control

postoperative IPCA is given alone

Group Type: ACTIVE_COMPARATOR

Morphine given as IPCA(intravenous patient controlled analgesia)

Intervention Type: DRUG

PCIA was initiated using a pump set to deliver boluses of 1.5-2 mg of morphine with a 5-minute lockout interval and no background infusion. The maximal permitted dosage of morphine was set at 8 mg/h.

Interventions

single-injection TQLB(transmuscular quadratus lumborum block)

Inject 0.6ml/kg local anesthetics in between quadratus lumborum and psoas major under ultrasound guidance

Intervention Type: PROCEDURE

Morphine given as IPCA(intravenous patient controlled analgesia)

PCIA was initiated using a pump set to deliver boluses of 1.5-2 mg of morphine with a 5-minute lockout interval and no background infusion. The maximal permitted dosage of morphine was set at 8 mg/h.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age 18-70 yrs
• American Society of Anesthesiologists physical statusⅠ-Ⅲ
• Undergo laparoscopic partial nephrectomy
• Informed consent

Exclusion Criteria

• A known allergy to the drugs being used
• Coagulopathy, on anticoagulants
• Analgesics intake, history of substance abuse
• Participating in the investigation of another experimental agent
• Inability to properly describe postoperative pain to investigators (eg, language barrier, neuropsychiatric disorder)

• Minimum Eligible Age: 17 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Cui Xulei

OTHER

Sponsor Role: lead

Responsible Party

Cui Xulei

attending physician

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Cui Xulei

Beijing, Beijing Municipality, China

Countries

China

Other Identifiers

cxl2

Identifier Type: -

Identifier Source: org_study_id