Comparison of Quadratus Lumborum Block and Epidural Analgesia Following Kidney Transplant Surgery
NCT ID: NCT03771339
Last Updated: 2020-10-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2018-12-10
2020-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Continuous Epidural Analgesia
Continuous epidural analgesia using ropivacaine 0.375% 3 mL boluses followed by ropivacaine 0.2% with rate 6 mL per hour for 24 hours
Continuous Epidural analgesia
Continuous Epidural catheter is inserted at the Thoracic 11-T12 level, using Ropivacaine 0.375% 3 mL bolus followed by Ropivacaine 0.2% with rate 6 mL/hour for 24 hours after laparoscopic nephrectomy
Bilateral Quadratus Lumborum Block
Bilateral Quadratus lumborum block using ropivacaine 0.2% 20 mL each injection after surgery
Bilateral Quadratus Lumborum block
Bilateral anterior Quadratus Lumborum block using Ropivacaine 0.375% 20 mL each injection as postoperative analgesia treatment for 24 hours
Interventions
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Continuous Epidural analgesia
Continuous Epidural catheter is inserted at the Thoracic 11-T12 level, using Ropivacaine 0.375% 3 mL bolus followed by Ropivacaine 0.2% with rate 6 mL/hour for 24 hours after laparoscopic nephrectomy
Bilateral Quadratus Lumborum block
Bilateral anterior Quadratus Lumborum block using Ropivacaine 0.375% 20 mL each injection as postoperative analgesia treatment for 24 hours
Eligibility Criteria
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Inclusion Criteria
* Agrees to participate in research
* BMI \< 30 kg/m2
Exclusion Criteria
* Contraindications to intervention procedures (epidural or quadratus lumborum block)
* History of local anaesthetic allergy
* Systemic allergic reactions, anaphylactic reaction, cardiac arrest
* Failure of intervention procedures (epidural or quadratus lumborum block)
* Intraoperative complications (massive bleeding, hypotension)
18 Years
80 Years
ALL
Yes
Sponsors
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Indonesia University
OTHER
Responsible Party
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Dita Aditianingsih
Principal investigator, Anesthesiologist Consultant
Principal Investigators
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Dita Aditianingsih, M.D.
Role: PRINCIPAL_INVESTIGATOR
Indonesia University
Locations
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Rumah Sakit Cipto Mangunkusumo
Jakarta Pusat, DKI Jakarta, Indonesia
Countries
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References
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Mochtar CA, Alfarissi F, Soeroto AA, Hamid ARAH, Wahyudi I, Marbun MBH, et al. Milestones of kidney transplantation in Indonesia. Med J Indones. 2017 Nov 27;26(3):229.
Kakaei F, Nikeghbalian S, Ali S. Kidney Transplantation Techniques. In: Rath T, editor. Current Issues and Future Direction in Kidney Transplantation [Internet]. InTech; 2013 [cited 2018 Jun 6]. Available from: http://www.intechopen.com/books/current-issues-and-future-direction-in-kidney-transplantation/kidney-transplantation-techniques
Pham PC, Khaing K, Sievers TM, Pham PM, Miller JM, Pham SV, Pham PA, Pham PT. 2017 update on pain management in patients with chronic kidney disease. Clin Kidney J. 2017 Oct;10(5):688-697. doi: 10.1093/ckj/sfx080. Epub 2017 Aug 18.
Abdelsalam K., Sultan S. Effectiveness of ultrasound-guided transversus abdominis plane block for intraoperative and postoperative analgesia in kidney transplantation. Ain-Shams J Anaesthesiol. 2015;8(1):140.
Srivastava D, Tiwari T, Sahu S, Chandra A, Dhiraaj S. Anaesthetic management of renal transplant surgery in patients of dilated cardiomyopathy with ejection fraction less than 40%. Anesthesiol Res Pract. 2014;2014:525969. doi: 10.1155/2014/525969. Epub 2014 Aug 19.
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Hirata ES, Baghin MF, Pereira RI, Alves Filho G, Udelsmann A. Influence of the anesthetic technique on the hemodynamic changes in renal transplantation: a retrospective study. Rev Bras Anestesiol. 2009 Mar-Apr;59(2):166-76. doi: 10.1590/s0034-70942009000200004. English, Portuguese.
Aulakh NK, Garg K, Bose A, Aulakh BS, Chahal HS, Aulakh GS. Influence of hemodynamics and intra-operative hydration on biochemical outcome of renal transplant recipients. J Anaesthesiol Clin Pharmacol. 2015 Apr-Jun;31(2):174-9. doi: 10.4103/0970-9185.155144.
Ueshima H, Otake H, Lin JA. Ultrasound-Guided Quadratus Lumborum Block: An Updated Review of Anatomy and Techniques. Biomed Res Int. 2017;2017:2752876. doi: 10.1155/2017/2752876. Epub 2017 Jan 3.
Krohg A, Ullensvang K, Rosseland LA, Langesaeter E, Sauter AR. The Analgesic Effect of Ultrasound-Guided Quadratus Lumborum Block After Cesarean Delivery: A Randomized Clinical Trial. Anesth Analg. 2018 Feb;126(2):559-565. doi: 10.1213/ANE.0000000000002648.
Mieszkowski MM, Mayzner-Zawadzka E, Tuyakov B, Mieszkowska M, Zukowski M, Wasniewski T, Onichimowski D. Evaluation of the effectiveness of the Quadratus Lumborum Block type I using ropivacaine in postoperative analgesia after a cesarean section - a controlled clinical study. Ginekol Pol. 2018;89(2):89-96. doi: 10.5603/GP.a2018.0015.
Lemmens HJ. Kidney transplantation: recent developments and recommendations for anesthetic management. Anesthesiol Clin North Am. 2004 Dec;22(4):651-62. doi: 10.1016/j.atc.2004.05.007.
Hockett MM, Hembrador S, Lee A. Continuous Quadratus Lumborum Block for Postoperative Pain in Total Hip Arthroplasty: A Case Report. A A Case Rep. 2016 Sep 15;7(6):129-31. doi: 10.1213/XAA.0000000000000363.
Mukhtar K, Khattak I. Transversus abdominis plane block for renal transplant recipients. Br J Anaesth. 2010 May;104(5):663-4. doi: 10.1093/bja/aeq077. No abstract available.
Tsai HC, Yoshida T, Chuang TY, Yang SF, Chang CC, Yao HY, Tai YT, Lin JA, Chen KY. Transversus Abdominis Plane Block: An Updated Review of Anatomy and Techniques. Biomed Res Int. 2017;2017:8284363. doi: 10.1155/2017/8284363. Epub 2017 Oct 31.
Schmid S, Jungwirth B. Anaesthesia for renal transplant surgery: an update. Eur J Anaesthesiol. 2012 Dec;29(12):552-8. doi: 10.1097/EJA.0b013e32835925fc.
Williams M, Milner QJ. Postoperative analgesia following renal transplantation - current practice in the UK. Anaesthesia. 2003 Jul;58(7):712-3. doi: 10.1046/j.1365-2044.2003.32661.x. No abstract available.
Nair A. Bilateral quadratus lumborum block for post-caesarean analgesia. Indian J Anaesth. 2017 Apr;61(4):362-363. doi: 10.4103/ija.IJA_204_17. No abstract available.
Ashok J, Mayur M, Asit K P, Neelam S.Postoperative Analgesia by Transmuscular Quadratus Lumborum Block Catheters. J Anest & Inten Care Med. 2016; 1(3) : 555562
Blanco R, Ansari T, Girgis E. Quadratus lumborum block for postoperative pain after caesarean section: A randomised controlled trial. Eur J Anaesthesiol. 2015 Nov;32(11):812-8. doi: 10.1097/EJA.0000000000000299.
Carline L, McLeod GA, Lamb C. A cadaver study comparing spread of dye and nerve involvement after three different quadratus lumborum blocks. Br J Anaesth. 2016 Sep;117(3):387-94. doi: 10.1093/bja/aew224.
Elsharkawy H. Quadratus Lumborum Blocks. Adv Anesth. 2017;35(1):145-157. doi: 10.1016/j.aan.2017.07.007. Epub 2017 Oct 3. No abstract available.
Garg C, Khanna S, Mehta Y. Quadratus lumborum block for post-operative pain relief in patient with Prune belly syndrome. Indian J Anaesth. 2017 Oct;61(10):840-842. doi: 10.4103/ija.IJA_246_17.
Shaaban M, Esa WA, Maheshwari K, Elsharkawy H, Soliman LM. Bilateral Continuous Quadratus Lumborum Block for Acute Postoperative Abdominal Pain as a Rescue After Opioid-Induced Respiratory Depression. A A Case Rep. 2015 Oct 1;5(7):107-11. doi: 10.1213/XAA.0000000000000188.
Akerman M, Pejcic N, Velickovic I. A Review of the Quadratus Lumborum Block and ERAS. Front Med (Lausanne). 2018 Feb 26;5:44. doi: 10.3389/fmed.2018.00044. eCollection 2018.
Agrawal P, Farag E. Ultrasound-guided quadratus lumborum and subcostal transversus abdominis plane blocks. Tech Reg Anesth Pain Manag. 2014 Oct;18(4):163-5
Brull R, MacFarlane AJR, Chan VWS. Spinal, Epidural, and Caudal Anesthesia. In: Miller RD, Cohen NH, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL, editors. Miller's anesthesia. Eighth edition. Philadelphia, PA: Elsevier/Saunders; 2015. p. 1684-720
Butterworth JF, Mackey DC, Wasnick JD, Morgan GE, Mikhail MS, Morgan GE. Spinal, Epidural, & Caudal Blocks. In: Morgan and Mikhail's clinical anesthesiology. 5th ed. McGraw-Hill; 2013. p. 937-74
Clemente A, Carli F. The physiological effects of thoracic epidural anesthesia and analgesia on the cardiovascular, respiratory and gastrointestinal systems. Minerva Anestesiol. 2008 Oct;74(10):549-63.
Wheatley RG, Schug SA, Watson D. Safety and efficacy of postoperative epidural analgesia. Br J Anaesth. 2001 Jul;87(1):47-61. doi: 10.1093/bja/87.1.47. No abstract available.
Grass JA. Patient-controlled analgesia. Anesth Analg. 2005 Nov;101(5 Suppl):S44-S61. doi: 10.1213/01.ANE.0000177102.11682.20.
Francesca F, Bader P, Echtle D, Giunta F, Williams J; EAU. EAU guidelines on pain management. Eur Urol. 2003 Oct;44(4):383-9. doi: 10.1016/s0302-2838(03)00321-x.
Other Identifiers
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IndonesiaUAnes030
Identifier Type: -
Identifier Source: org_study_id