Acute Effect of Isometric Exercise on Blood Pressure in Hypertensive Patients

NCT ID: NCT03982758

Last Updated: 2021-07-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-09

Study Completion Date

2022-03-18

Brief Summary

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International recommendations advocate dynamic or isometric strength training as an adjunct to aerobic exercise. Due to a lack of consensus, this research addresses the acute effects of isometric exercises by handgrip or lower limb isometry as a hypotensive strategy in hypertensive adults.

Detailed Description

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This study is characterized as a randomized, controlled and blinded clinical trial for the evaluators and carried out integrally in the Laboratory of Clinical Investigation (LIC) of the Cardiology Institute of Rio Grande do Sul / University Foundation of Cardiology (ICFUC). The project follows all recommendations proposed by the CONSORT Statement.

The study will consist of individuals of both genders, aged between 40 and 70 years who have blood pressure above 120mmhg by 80mhg. The participants, after signing the informed consent, answered a questionnaire that will evaluate the habitual level of physical activity and will be submitted to isometric exercises of palmar grip or quadriceps muscle. Pre- and post-exercise blood pressure will be monitored through the ambulatory blood pressure monitoring (ABPM) method.

Conditions

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Arterial Hypertension

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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isometric handgrip exercise

Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.

Group Type EXPERIMENTAL

isometric handgrip exercise

Intervention Type OTHER

Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.

isometric of lower limbs

Isometric session for lower limbs: 4 series with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute.

Group Type EXPERIMENTAL

isometric of the lower limbs

Intervention Type OTHER

Isometric session for lower limbs: 4 sets with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute rest.

Interventions

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isometric handgrip exercise

Isometric session with handgrip: 4 sets of 2 minutes of contractions sustained at 30% of CVM, for each arm. The time between sets and between arms will be 1 minute rest.

Intervention Type OTHER

isometric of the lower limbs

Isometric session for lower limbs: 4 sets with 2 minutes of contractions sustained at 30% of 1RM. The rest interval will be 1 minute rest.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Controlled hypertensive patients (use of medication) sedentary or physically inactive

Exclusion Criteria

* Pregnant women;
* Unstable angina;
* Class II, III or IV heart failure;
* Recent cardiovascular event (last 3 months);
* Chronic renal insufficiency;
* Diabetes;
* History of malignant diseases with life expectancy \<2 years;
* Or Orthopedic limitations or any physical or mental limitation that impedes the performance of physical exercises.
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Instituto de Cardiologia do Rio Grande do Sul

OTHER

Sponsor Role lead

Responsible Party

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Patricia Caetano

principal investigador

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Patricia Caetano, graduate

Role: PRINCIPAL_INVESTIGATOR

Instituto de Cardiologia/ Fundação Universitária de Cardiologia

Locations

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Instituto de Cardiologia/ fundação Universitária de Cardiologia

Porto Alegre, Rio Grande do Sul, Brazil

Site Status RECRUITING

Countries

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Brazil

Central Contacts

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Patrícia Caetano, graduate

Role: CONTACT

+5551992039364

Alexandre Lehnen, PHD

Role: CONTACT

+555199768092

Facility Contacts

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Patrícia C de Oliveira

Role: primary

(51)992039364

Instituto de Cardiologia

Role: backup

5132303600 ext. 4124

References

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Oliveira PC, Dipp T, Waclawovsky G, Lehnen AM. Post-isometric exercise hypotension occurs irrespective of muscle mass in adults with hypertension: A randomized clinical trial. Clinics (Sao Paulo). 2025 Apr 16;80:100612. doi: 10.1016/j.clinsp.2025.100612. eCollection 2025.

Reference Type DERIVED
PMID: 40245790 (View on PubMed)

Other Identifiers

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PCaetano

Identifier Type: -

Identifier Source: org_study_id

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