Lifestyle Changes in Patients With Type 2 Diabetes Mellitus and Hypertension

NCT ID: NCT01461330

Last Updated: 2017-01-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2013-11-30

Brief Summary

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Data obtained in hypertensive patients without diabetes suggest that increased association of non-pharmacological treatment in patients with diabetes and hypertension may be associated with an improvement in blood pressure control. Despite the beneficial results found, is not yet known the magnitude of the effect of a DASH diet associated with the stimulus of physical activity on BP in patients with type 2 diabetes. The beneficial effects on blood pressure of an additional non-pharmacological intervention to drug therapy may have an even greater impact in patients with treatment-resistant hypertension The aim of this study is to evaluate the effect of changes in lifestyle on blood pressure in patients with type 2 diabetes and hypertension resistant to treatment.

Detailed Description

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The aim of this study is to evaluate the effect of changes in lifestyle on blood pressure in patients with type 2 diabetes and hypertension. Secondary objectives are: Assess whether the prescription of a DASH-type diet and encouragement for physical activity through use of pedometers, can improve blood pressure control in patients with type 2 diabetes and hypertension resistant to treatment.

Forty type 2 diabetic with resistant hypertension outpatients were included in a randomized clinical trial: treatment 1- DASH diet + encouragement for physical activity through use of pedometer; treatment 2- ADA diet + usual exercises. The duration of each treatment are four weeks. The patients included should have performed Ambulatory Blood Pressure Monitoring (ABPM) to exclude white-coat effect, ie when there are abnormal in the measurement of office blood pressure (equal to or above 140/90 mm Hg) and normal blood pressure by ABPM during the awake period (equal to or below 135/85 mm Hg). Twenty-four hour records with concurrent 24h urinary collections (protein intake estimative), clinical and laboratory evaluation were performed at baseline and after 4 weeks. Serum fatty acids were measured in total lipids by gas chromatography.

Conditions

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Blood Pressure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

intervention: DASH diet plus exercise DASH diet adapted to the usual diet of Brazilian type 2 diabetic patients = prescription of a normocaloric diet including fruits, vegetables, grain products, low fat dairy foods, legumes, without sugar, and with limited fat Exercises: the recommended physical activity will consist of using a pedometer during the experimental period.

active comparator = ADA diet = Adoption of ADA diet.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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DASH diet

DASH DIET + EXERCISE

Group Type EXPERIMENTAL

DASH diet plus exercise

Intervention Type OTHER

DASH diet adapted to the usual diet of Brazilian type 2 diabetic patients = prescription of a normocaloric diet including fruits, vegetables, grain products, low fat dairy foods, legumes, without sugar, and with limited fat

Exercises: the recommended physical activity will consist of using a pedometer during the experimental period.

ADA DIET

DIET ACCORDING AMERICAN DIABETES ASSOCIATION DIETARY RECOMMENDATIONS FOR DIABETES

Group Type ACTIVE_COMPARATOR

ADA diet

Intervention Type OTHER

Adoption of ADA diet.

Interventions

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DASH diet plus exercise

DASH diet adapted to the usual diet of Brazilian type 2 diabetic patients = prescription of a normocaloric diet including fruits, vegetables, grain products, low fat dairy foods, legumes, without sugar, and with limited fat

Exercises: the recommended physical activity will consist of using a pedometer during the experimental period.

Intervention Type OTHER

ADA diet

Adoption of ADA diet.

Intervention Type OTHER

Other Intervention Names

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LYFESTYLE INTERVENTION Active comparator: ADA DIET

Eligibility Criteria

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Inclusion Criteria

* type 2 diabetes
* Blood pressure ≥140/90 mm Hg
* ABMP ≥ 135/85 mm Hg

Exclusion Criteria

* digestive disease with malabsorption
* diabetic neuropathy with gastroparesis
* BMI ≥ 40 kg/m²
Minimum Eligible Age

30 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital de Clinicas de Porto Alegre

OTHER

Sponsor Role lead

Responsible Party

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Mirela Jobim de Azevedo

Dr., MD, Associated Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Tatiana P de Paula, RD

Role: STUDY_CHAIR

Hospital de Clínicas de Porto Alegre

Luciana Verzoça, MD

Role: STUDY_CHAIR

Hospital de Clínicas de Porto Alegre

Locations

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Hospital de Clínicas de Porto Alegre

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

Countries

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Brazil

Other Identifiers

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HCPA 10-0411

Identifier Type: -

Identifier Source: org_study_id

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