Epidemiological, Clinical, Microbiological and Outcome Description of Patients With Klebsiella sp Meningitis

NCT ID: NCT03967210

Last Updated: 2021-08-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 132 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-07-05
• Study Completion Date: 2020-01-13

Brief Summary

Klebsiella pneumoniae is implicated in the occurrence of severe pneumonia. Most Klebsiella pneumoniae infections are associated with care and occur in patients with compromised immune defenses. More recently, cases of hepatic abscess and acute community meningitis related to strains of Klebsiella pneumoniae have been reported. The mortality of these infections is important, most often due to a delayed diagnosis. The poor prognostic factors reported in the literature for very low numbers are: advanced age, coma, septic shock, glyceryachia <10mg / dL and proteinuria> 750 mg / dL. In addition, no study has specifically focused on the factors of occurrence and factors associated with Klebsiella sp. Indeed, meningitis related to Klebsiella pneumoniae seems to be a rare but probably underestimated event whose risk factors, clinical presentation, microbiological are little known and the treatment modalities of this severe infection are not codified.

Conditions

Meningitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Man or Woman whose age ≥ 18 years
• Patient with meningitis Klebsiella sp., hospitalized in one of the hospitals of the Clinical Microbiology Group
• Francophone patient

Exclusion Criteria

• Patient under tutorship or curatorship
• Patient deprived of liberty
• Patient under safeguard of justice
• Patient opposing his participation

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fondation Hôpital Saint-Joseph

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Benoit PILMIS, MD

Role: STUDY_DIRECTOR

Fondation Hôpital Saint-Joseph

Locations

CHU Brest

Brest, , France

CHU Caen

Caen, , France

Hôpital henri Mondor

Créteil, , France

CHU Lyon

Lyon, , France

CHU Nantes

Nantes, , France

CHU Nice

Nice, , France

Hôpital Lariboisière

Paris, , France

Groupe Hospitalier Paris Saint-Joseph

Paris, , France

Hôpital Cochin

Paris, , France

CHU Kremlin Bicetre

Paris, , France

Hôpital Foch

Paris, , France

Hôpital Necker Enfants Malades

Paris, , France

Hôpital Sainte Anne

Paris, , France

CHU Poitiers

Poitiers, , France

CHU Reims

Reims, , France

CHU Rennes

Rennes, , France

CHU Strasbourg

Strasbourg, , France

CHU Tours

Tours, , France

Countries

France

Other Identifiers

KlebsieLCR

Identifier Type: -

Identifier Source: org_study_id