Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)

NCT ID: NCT03946085

Last Updated: 2019-05-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

79 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-19

Study Completion Date

2018-11-01

Brief Summary

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The aim of this study is to evaluate the clinical benefits in visual function from dietary supplementation of the Lumega-Z carotenoid liquid-supplement in participants with drusen and at risk of AMD. The effects of Lumega-Z supplementation will be compared to an active comparator, the AREDS2 multivitamin.

Detailed Description

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Conditions

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Retinal Drusen Age-related Macular Degeneration Macular Degeneration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel treatment group participants will be randomly assigned either the experimental intervention, Lumega-Z, or the AREDS2 supplement. An observational, control group will be included for further comparison.
Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Lumega-Z group

Participants assigned the study supplement Lumega-Z.

Group Type EXPERIMENTAL

Lumega-Z

Intervention Type DIETARY_SUPPLEMENT

A specially-formulated carotenoid supplement formula that utilizes a micronized, lipid-based liquid form of delivery.

AREDS2 group

Participants assigned the AREDS2 supplement

Group Type ACTIVE_COMPARATOR

AREDS2

Intervention Type DIETARY_SUPPLEMENT

A commercially-available multivitamin soft gel formula.

Control

Participants are determined ocular normal after clinical examination and do not have retinal drusen.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Lumega-Z

A specially-formulated carotenoid supplement formula that utilizes a micronized, lipid-based liquid form of delivery.

Intervention Type DIETARY_SUPPLEMENT

AREDS2

A commercially-available multivitamin soft gel formula.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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LMZ Preservision Age-Related Eye Disease Study 2 (AREDS2)

Eligibility Criteria

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Inclusion Criteria

\- patients with retinal drusen (as determined by clinical fundus photography examination) and dark adaptation recovery time of 6 to 10 minutes.

Exclusion Criteria

* presence of congenital retinal pathologies that may impact data collection
* prior history of retinal-detachment or vitreo-retinal surgeries with any complications
* best-corrected visual acuity of 20/40 or worse
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Western University of Health Sciences

OTHER

Sponsor Role collaborator

Eye Clinic of Austin

OTHER

Sponsor Role collaborator

Guardion Health Sciences, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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T Henderson

Role: PRINCIPAL_INVESTIGATOR

Eye Clinic of Austin

Locations

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Eye Clinic of Austin

Austin, Texas, United States

Site Status

Countries

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United States

References

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Davey PG, Henderson T, Lem DW, Weis R, Amonoo-Monney S, Evans DW. Visual Function and Macular Carotenoid Changes in Eyes with Retinal Drusen-An Open Label Randomized Controlled Trial to Compare a Micronized Lipid-Based Carotenoid Liquid Supplementation and AREDS-2 Formula. Nutrients. 2020 Oct 26;12(11):3271. doi: 10.3390/nu12113271.

Reference Type DERIVED
PMID: 33114566 (View on PubMed)

Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

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Protocol Number 2

Identifier Type: -

Identifier Source: org_study_id

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