Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation for Two More Years (LUTEGA 2)

NCT ID: NCT01648660

Last Updated: 2013-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-05-31

Study Completion Date

2012-12-31

Brief Summary

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The primary objective of LUTEGA 2 is it to determine the long term effect (about 2 more years after LUTEGA 1, NCT00763659) of the supplementation with a fixed combination of lutein/zeaxanthin and omega-3- fatty acids in two different dosages on the optical density (OD) of macular pigment in patients with non- exudative age related maculopathy. The dosage groups are crossed after LUTEGA 1.

Detailed Description

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The LUTEGA 2 is a cross-over- study and the continue of LUTEGA 1. After one year of supplementation in randomized, placebo- controlled, double blind study (LUTEGA 1), the treatment arms are unblind to cross over the different dosage groups.

The measurement of optical density of macular pigment (MPOD) uses the 1- wavelength reflection method recording reflection images at 480 nm by a fundus camera. The patients are followed up over two years in eight more visits (every three months) In addition to the MPOD- measurement each examination includes standardized visual acuity test (ETDRS), amsler- grid, slit lamp biomicroscopy, fundus photography (color and autofluorescence) and a blood sample (every six months).

Conditions

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Age Related Maculopathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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D2x - D1x

Cross Over from double dosage to single dosage:

daily supplementation with 10mg Lutein, 1mg Zeaxanthin, 255 mg Omega-3-FAabout two years after one year with 20mg Lutein, 2mg Zeaxanthin, 510 mg Omega-3-FA

Group Type ACTIVE_COMPARATOR

Lutein/ Zeaxanthin + Omega- 3- Fatty Acids

Intervention Type DIETARY_SUPPLEMENT

capsule with Lutein, Zeaxanthin, Omega-3-FA for two years

D1x - D2x

Cross Over from double dosage to single dosage:

daily supplementation with 20mg Lutein, 2mg Zeaxanthin, 510 mg Omega-3-FA about two years after one year with 10mg Lutein, 1mg Zeaxanthin, 255 mg Omega-3-FA

Group Type ACTIVE_COMPARATOR

Lutein/ Zeaxanthin + Omega- 3- Fatty Acids

Intervention Type DIETARY_SUPPLEMENT

capsule with Lutein, Zeaxanthin, Omega-3-FA for two years

D1x - D1x

single dosage: daily supplementation about two years after one year with 10mg Lutein, 1mg Zeaxanthin, 255 mg Omega-3-FA (dosage remains existing)

Group Type ACTIVE_COMPARATOR

Lutein/ Zeaxanthin + Omega- 3- Fatty Acids

Intervention Type DIETARY_SUPPLEMENT

capsule with Lutein, Zeaxanthin, Omega-3-FA for two years

Interventions

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Lutein/ Zeaxanthin + Omega- 3- Fatty Acids

capsule with Lutein, Zeaxanthin, Omega-3-FA for two years

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* All non- exudative forms of age related maculopathy

Exclusion Criteria

* Exudative age related maculopathy
* decrease opacity of ocular media
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Jena

OTHER

Sponsor Role lead

Responsible Party

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Jens Dawczynski

Prof. Dr. med. Jens Dawczynski

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jürgen Strobel, MD

Role: STUDY_DIRECTOR

University Hospital Jena

Jens Dawczynski, MD

Role: PRINCIPAL_INVESTIGATOR

University of Leipzig

Other Identifiers

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2032- 06/07

Identifier Type: -

Identifier Source: org_study_id

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