The Effect of Periodontal Treatment on Psoriasis

NCT ID: NCT03939936

Last Updated: 2019-05-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

92 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-01

Study Completion Date

2018-02-15

Brief Summary

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There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

Detailed Description

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The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Conditions

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Periodontal Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Test Group

Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks.

Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Group Type ACTIVE_COMPARATOR

Psoriatic measurements

Intervention Type OTHER

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Non-surgical periodontal treatment

Intervention Type OTHER

Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

saliva samples

Intervention Type OTHER

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Control Group

Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment.

Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Group Type PLACEBO_COMPARATOR

Psoriatic measurements

Intervention Type OTHER

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

saliva samples

Intervention Type OTHER

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Interventions

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Psoriatic measurements

Psoriasis Area and Severity Index (PASI) was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Intervention Type OTHER

Non-surgical periodontal treatment

Non-surgical periodontal treatment was performed baseline and after 8 weeks. Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Intervention Type OTHER

saliva samples

Saliva samples were taken from patients for the evaluation of proinflammatory cytokine baseline and after 8 weeks.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* the presence at least 20 remaining teeth,
* the presence of Stage I or Stage II Periodontitis,
* the presence of diagnosed psoriasis.

Exclusion Criteria

* patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
* patients who received periodontal treatment prior to 6 months,
* women who were breastfeeding or pregnant,
* patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ozge Gokturk

OTHER

Sponsor Role lead

Responsible Party

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Ozge Gokturk

Principal Investigator

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Atiye Ogrum

Role: PRINCIPAL_INVESTIGATOR

Gaziosmanpasa Universty

Locations

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Gaziosmanpasa University

Tokat Province, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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17-KAEK-44

Identifier Type: -

Identifier Source: org_study_id

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