Aloe Vera Ointment Application and Skeletal Muscle Recovery
NCT ID: NCT03934762
Last Updated: 2020-01-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
10 participants
INTERVENTIONAL
2019-04-25
2019-05-30
Brief Summary
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Exercise training, especially when it is unaccustomed or characterized by increased intensity, results in skeletal muscle microtrauma accompanied by elevated plasma levels of Creatine Kinase (CK), increased sensation of muscle soreness (DOMS), reduced force generating capacity and marked declines in speed and agility. Both anti-inflammatory and antioxidative mechanisms in skeletal muscle are crucial for the termination of inflammatory response and muscle healing process following exercise-induced aseptic muscle injury and inflammation.
Although, it has been proposed that ale vera may elicit anti-inflammatory and antioxidative activity, its effectiveness in alleviating exercise-induced skeletal muscle injury and its symptoms, has not been investigated yet. Therefore, the aim of the present pilot study is to examine the effect of transdermal aloe veral delivery on skeletal muscle damage symptoms following an intense eccentric exercise protocol.
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Detailed Description
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Initially, participants will undergo a baseline testing including assessment of body height, body mass and body composition, isokinetic evaluation of isometric, concentric and eccentric muscle strength of quadriceps, determination of VO2max, evaluation of DOMS level and resting blood sampling for the measurement of CK. Participants will be also provided with 7-day diet recalls and will be taught by a trained dietitian on how to adjust food/liquid portions and sizes and how to complete diet recalls (1 recall/day over a 7-day period).
After baseline testing, subjects will participate in two trials, in a randomized, double-blind repeated measures design. In the first trial they will execute a bilateral eccentric exercise protocol. Immediately after the exercise protocol and daily for 7 consecutive days, will be applied transdermal treatment with placebo (Control) in one leg and with natural aloe vera (Experimental, aloe vera peel and leaf) in the other. Following a 7-day wash-out period the second trial will be conducted. Participants will execute the same eccentric exercise protocol, but they will be treated with either placebo (Control) or aloe vera soup (Experimental). The selection of the treatment for each leg will be randomly selected. In both trials, assessment of DOMS and strength (isometric, concentric and eccentric) in both legs and blood sampling (for the measurement of CK) will be performed at 1h and 6h post-exercise as well as daily for 7 consecutive days.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
DOUBLE
Study Groups
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Placebo
A placebo solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.
Placebo
A placebo solution that will not include aloe vera will be applied on the quadriceps of one of the lower limbs.
Natural aloe vera
A natural aloe vera solution (peel and leaf) will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.
Natural Aloe Vera
Natural aloe vera solution including peel and leaf from aloe will be applied on the the quadriceps of one of the lower limbs.
Aloe vera soup
An aloe vera soup solution will be applied on the quadriceps of one of the lower limbs immediately after the exercise protocol and daily for 7 consecutive days.
Aloe vera soup
Aloe vera solution including aloe vera soup will be applied on the the quadriceps of one of the lower limbs.
Interventions
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Placebo
A placebo solution that will not include aloe vera will be applied on the quadriceps of one of the lower limbs.
Natural Aloe Vera
Natural aloe vera solution including peel and leaf from aloe will be applied on the the quadriceps of one of the lower limbs.
Aloe vera soup
Aloe vera solution including aloe vera soup will be applied on the the quadriceps of one of the lower limbs.
Eligibility Criteria
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Inclusion Criteria
* No consumption of performance-enhancing supplements or medication for at least 6 months prior to the study.
* No consumption of anti-inflammatory and antioxidant supplements for at least 6 months prior to the study.
* No participation in exercise including eccentric muscle contractions for at least 3 days prior to the study.
Exclusion Criteria
* Consumption of performance-enhancing supplements and medication.
* Consumption of anti-inflammatory and antioxidant supplements (\> 6 months).
* Participation in exercise including eccentric muscle contractions during the last 3 days prior to the study.
18 Years
25 Years
MALE
Yes
Sponsors
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University of Thessaly
OTHER
Responsible Party
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Ioannis G. Fatouros
Professor
Locations
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SmArT LABORATORY, SCHOOL OF PHYSICAL EDUCATION & SPORTS SCIENCES, UNIVERSITY OF THESSALY
Trikala, , Greece
Countries
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Other Identifiers
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ALOE VERA-PILOT STUDY-UTH
Identifier Type: -
Identifier Source: org_study_id
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