Serum and Urine Ghrelin in Adult Epileptic Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-06-01

Study Completion Date

2019-02-05

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6

NCT06565338

Traumatic Brain Injury

COMPLETED

Ketogenic Diet for Traumatic Brain Injury

NCT03982602

Traumatic Brain Injury Ketogenic Dieting

COMPLETED EARLY_PHASE1

Dexmedetomidine on Brain Injury Patients

NCT06661980

Brain Injuries

COMPLETED NA

Mgso4 as Neuroprotective in Post Traumatic Brain Injury

NCT04646876

Magnesium Sulphate Traumatic Brain Injury Brain +1 more

COMPLETED PHASE3

Ghrelin (OXE--103) for Acute Concussion Management

NCT04558346

Concussion, Brain Traumatic Brain Injury

COMPLETED PHASE2

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response. Objective: to evaluate ghrelin effect in adult epileptic patients and in response to AED. Methods: This case control study included 40 adult epileptic patients and 40 healthy controls. Participants were subjected to history taking of seizure semiology, full general and neurological examination, electroencephalography and cranial CT or MRI. Fasting serum acylated ghrelin (AG) and unacylated ghrelin (UAG) and urine AG levels were estimated to all participants by enzyme - linked immunosorbent assay (ELIZA).

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Epilepsy

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

OTHER

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

group 1

Epileptic participants group consisted of 40 adults (15 females and 25 males) clinically and electrophysiological were diagnosed according to the international league against epilepsy classification 2010.

No interventions assigned to this group

group 2

Control group consisted of 40 adults (16 females and 24 males) non - epileptic healthy subjects.

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All participants were included if their age more than or equal to 18 years. Body mass index \< 30 kg/m2, total cholesterol \< 200mg/dl, serum triglycerides \< 200 mg/dl and random blood glucose level \< 126 mg/dl.

Exclusion Criteria

* Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders).
* Females with irregular menstrual cycle or on estrogen therapy (7).
* Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI).

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No