Effect of Daily Use Proton Pump Inhibitors for One Month on Kidney Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-12-31

Study Completion Date

2021-10-31

Brief Summary

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The aim of this study to: evaluate the association between prolonged use of PPI and adverse renal outcomes on patients with normal renal function and others with abnormal renal function

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Detailed Description

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Proton pump inhibitors (PPIs) are one of the most widely used classes of drugs and are prescribed primarily for gastric acid-related diseases, eradication of Helicobacter pylori, and prevention of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy,and gastroesophagial reflux diseases . Although PPIs have an excellent overall safety profile, some severe adverse effects, which include bone fracture, dementia, myocardial infarction, infections, micronutrient deficiencies, and kidney diseases,PPIs may trigger acute interstitial nephritis,a potentially sever adverse event commonly associated with acute kidney injury The increase in prescription and inadequate use of this class of medication calls for studies on the effects of prolonged PPI therapy on renal function.

Conditions

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Proton Pump Inhibitor Allergy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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pantoprazole with normal kidney function

use pantoprazole for one month and after one month i will do for them kidney functions test

Group Type EXPERIMENTAL

pantoprazole

Intervention Type DRUG

effect of this drug on renal function

pantoprazole with abnormal kidney function

use pantoprazole for one month and after one month i will do for them kidney functions test

Group Type EXPERIMENTAL

pantoprazole

Intervention Type DRUG

effect of this drug on renal function

Interventions

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pantoprazole

effect of this drug on renal function

Intervention Type DRUG

Other Intervention Names

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Protonix

Eligibility Criteria

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Inclusion Criteria

* patients with peptic ulcer disease or gastroesophagial reflux with normal l renal function
* patients with peptic ulcer disease or gastroeosophagial reflux with abnormal renal function

Exclusion Criteria

* 1- cigarette smoker: Cigarette smoking status was defined categorically as current,former, or never smoker at baseline.

2-biabetic patients: diabetes mellitus is defined by a fasting blood glucose concentration \>\_ 126 mg/dl ,random glucose level of \>200 mg/dl.

3-patients take corticosteroid 4-patients with hypersensitivity to these drugs

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes