An International Study to Evaluate the Real-world Effectiveness and Usage of Alprolix in Patients With Haemophilia B

NCT ID: NCT03901755

Last Updated: 2025-09-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

151 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-09-12

Study Completion Date

2024-03-12

Brief Summary

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Alprolix (rFIXFc) is a recombinant extended half-life coagulation factor product. The purpose of this non-interventional study is to describe the real-world usage and effectiveness of Alprolix in the on-demand and prophylactic treatment of haemophilia B.

Detailed Description

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Conditions

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Hemophilia B

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Prophylactic patients

Alprolix will be prescribed according to local practice and administered by patients with haemophilia B for prophylactic treatment

Alprolix

Intervention Type DRUG

Extended half-life factor IX product

On demand patients

Alprolix will be prescribed according to local practice and administered by patients with haemophilia B for on-demand treatment

Alprolix

Intervention Type DRUG

Extended half-life factor IX product

Interventions

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Alprolix

Extended half-life factor IX product

Intervention Type DRUG

Other Intervention Names

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Eftrenonacog alfa rFIXFc

Eligibility Criteria

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Inclusion Criteria

* Have a diagnosis of haemophilia B
* Have started Alprolix treatment prior to enrolment visit, or at enrolment prescribed treatment with Alprolix irrespective of participation in the study
* Signed and dated informed consent provided by the patient, or the patients legally acceptable representative for patients under the legal age, before any study-related activities are undertaken. Assent should be obtained from paediatric patients according to local regulations.

Exclusion Criteria

* Participation in an investigational medicinal product trial at enrolment visit
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Swedish Orphan Biovitrum

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elena Santagostino, MD

Role: STUDY_DIRECTOR

Swedish Orphan Biovitrum

Locations

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Swedish Orphan Biovitrum Research Site

Brno, , Czechia

Site Status

Swedish Orphan Biovitrum Research Site

Prague, , Czechia

Site Status

Swedish Orphan Biovitrum Research Site (Haemophilia Center Aghia Sophia Children's Hospital)

Athens, , Greece

Site Status

Swedish Orphan Biovitrum Research Site (Laikο General Hospital of Athens)

Athens, , Greece

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Swedish Orphan Biovitrum Research Site

Dublin, , Ireland

Site Status

Swedish Orphan Biovitrum Research Site

Bari, , Italy

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Swedish Orphan Biovitrum Research Site

Florence, , Italy

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Swedish Orphan Biovitrum Research Site

Genova, , Italy

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Swedish Orphan Biovitrum Research Site

Milan, , Italy

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Swedish Orphan Biovitrum Research Site

Roma, , Italy

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Swedish Orphan Biovitrum Research Site

Turin, , Italy

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Swedish Orphan Biovitrum Research Site

Oslo, , Norway

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Swedish Orphan Biovitrum Research Site (King Faisal Hospital adult)

Riyadh, , Saudi Arabia

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Swedish Orphan Biovitrum Research Site (King Faisal Hospital pediatric)

Riyadh, , Saudi Arabia

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Swedish Orphan Biovitrum Research Site (Hospital de Vall d'Hebrón)

Barcelona, , Spain

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Swedish Orphan Biovitrum Research Site (Hospital Sant Joan de Deu)

Barcelona, , Spain

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Swedish Orphan Biovitrum Research Site

Murcia, , Spain

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Swedish Orphan Biovitrum Research Site

Vigo, , Spain

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Swedish Orphan Biovitrum Research Site

Gothenburg, , Sweden

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Swedish Orphan Biovitrum Research Site

Malmo, , Sweden

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Swedish Orphan Biovitrum Research Site (Karolinska University Hospital adult)

Stockholm, , Sweden

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Swedish Orphan Biovitrum Research Site (Karolinska University Hospital pediatric)

Stockholm, , Sweden

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Swedish Orphan Biovitrum Research Site

Hull, , United Kingdom

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Swedish Orphan Biovitrum Research Site

London, , United Kingdom

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Swedish Orphan Biovitrum Research Site

London, , United Kingdom

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Swedish Orphan Biovitrum Research Site

London, , United Kingdom

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Swedish Orphan Biovitrum Research Site

London, , United Kingdom

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Swedish Orphan Biovitrum Research Site

Manchester, , United Kingdom

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Swedish Orphan Biovitrum Research Site

Oxford, , United Kingdom

Site Status

Countries

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Czechia Greece Ireland Italy Norway Saudi Arabia Spain Sweden United Kingdom

Other Identifiers

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Sobi.Alprolix-002

Identifier Type: -

Identifier Source: org_study_id

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