Effects of Breaking up Prolonged Sitting on Postprandial Cardiometabolic Disease Risk Markers in South Asian Adults

NCT ID: NCT03898206

Last Updated: 2019-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-26

Study Completion Date

2020-02-25

Brief Summary

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The purpose of this study is to examine whether breaking up prolonged sitting with short regular bouts of walking can reduce blood sugar and cholesterol levels after eating, which are risk markers for Type 2 diabetes and heart disease. This study will compare these responses in normal weight versus overweight/obese South Asian adults.

Detailed Description

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Participants will attend a preliminary testing session where height, weight, body fat and waist circumference will be measured. They will be familiarised with a motorised treadmill that will be used during the experimental visit below and will take part in an exercise test to determine a light-intensity walking speed for the experimental visit.

Participants will then attend two experimental visits in a random order:

1. Prolonged sitting: Participants will remain seated for 5 hours and instructed to reduce excessive movement.
2. Breaking up sitting with walking breaks: Participants will rise from the seated position every 30 minutes throughout the experimental period to walk on a motorised treadmill at a light intensity for 3 minutes. After performing walking activity, they will return to the seated position. In addition, blood sample will be taken at the resting position just before each physical activity bout. The activity breaks will be undertaken on 9 occasions, providing a total of 27 min of light intensity activity.

During each visit, blood pressure will be taken 11 times and blood samples will be taken 10 times. Participants will be given a breakfast and lunch meal to consume.

Conditions

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Cardiovascular Risk Factor Cardiovascular Diseases Diabetes Physical Activity Sedentary Lifestyle

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Prolonged sitting

Participants will remain seated for 5 h and instructed to reduce excessive movement, only rising from the chair to void.

Group Type EXPERIMENTAL

Prolonged sitting

Intervention Type OTHER

See Prolonged sitting arm description

Breaking up sitting with walking breaks

Participants will rise from the seated position every 30 min throughout the experimental period to walk on a motorised treadmill at a light intensity walking (as determined during the preliminary test) for 3 min. Participants will start walk on a treadmill at 30 min (so physical activity would be at 30-33 min), 60 min (physical activity will be at 60-63 min), 90 min (physical activity will be at 90-93 min), 120 min (physical activity will be 120-123 min), 150 min (physical activity will be at 150-153 min ), and 180 min (physical activity will be at 180-183 min) in the breakfast postprandial period and 30 min (physical activity will be 30-33 min), 60 min (physical activity will be at 60-63 min), and 90 min (physical activity will be at 90-93 min) in the lunch postprandial period. After performing walking activity, they will return to the seated position.

Group Type EXPERIMENTAL

Breaking up sitting with walking breaks

Intervention Type OTHER

See Breaking up sitting with walking breaks arm description

Interventions

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Breaking up sitting with walking breaks

See Breaking up sitting with walking breaks arm description

Intervention Type OTHER

Prolonged sitting

See Prolonged sitting arm description

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Self-identified South Asian ethnicity.
* Self-report sitting at least 7 hours per day.
* Normal weight, overweight or obese.

Exclusion Criteria

* Unable to speak and read English.
* Contraindications to performing light-intensity walking.
* Diagnosed cardiovascular disease or diabetes.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Bedfordshire

OTHER

Sponsor Role lead

Responsible Party

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Daniel Bailey

Senior Lecturer in Health, Nutrition and Exercise

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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University of Bedfordshire

Bedford, Bedfordshire, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Facility Contacts

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Daniel Bailey, PhD

Role: primary

01234793237

Other Identifiers

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2019ISPAR003

Identifier Type: -

Identifier Source: org_study_id

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