Combined Anodal Transcranial Direct Current Stimulation (tDCS) and Cognitive Training and Decision-making
NCT ID: NCT03886025
Last Updated: 2025-08-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2022-09-15
2026-12-30
Brief Summary
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Detailed Description
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To examine these issues further, a single blind parallel arms randomized controlled trial will be conducted, involving a sample of healthy volunteers aged between 18 and 40. This will entail applying either active or sham tDCS over the anterior frontal cortex (including the vm-PFC) while participants undertake decision-making training using the Iowa Gambling Task. Decision-making will be assessed using the IGT, which is a computerized gambling task used to assess decision-making under conditions of uncertainty and risk. IGT is sensitive to damage to the ventromedial prefrontal cortex (vmPFC), which is considered to play a key role in decision-making. Motor impulsivity will be measured using the Stop Signal Task (SST). The UPPS+P Impulsive Behaviour Scale will be used to index trait impulsivity. The Profile of Mood States will be used to measure state emotion before and after tDCS.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Combined anodal tDCS and cognitive training
Combined anodal tDCS and cognitive training. Anodal tDCS will be delivered while the participant is completing the cognitive training task (Iowa Gambling Task). Anodal tDCS will use a constant current of 2mA, delivered via gradual increase and decrease over 10 seconds at the onset and offset of stimulation (current ramps), respectively. The duration of each tDCS session will be 20 minutes.
Anodal transcranial Direct Current Stimulation (tDCS)
Non-invasive brain stimulation
Cognitive training
Iowa Gambling Task will be used for cognitive training
Combined sham tDCS and cognitive training
Combined sham tDCS and cognitive training. Sham tDCS will be delivered while the participant is completing the cognitive training task (Iowa Gambling Task). For sham tDCS, the current will be delivered only in the first 10 seconds, after which the stimulation will cease but with the electrodes still in place throughout the session. The duration of each tDCS session will be 20 minutes.
Cognitive training
Iowa Gambling Task will be used for cognitive training
Sham transcranial Direct Current Stimulation (tDCS)
Non-invasive brain stimulation
Interventions
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Anodal transcranial Direct Current Stimulation (tDCS)
Non-invasive brain stimulation
Cognitive training
Iowa Gambling Task will be used for cognitive training
Sham transcranial Direct Current Stimulation (tDCS)
Non-invasive brain stimulation
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Individuals with a history of substance misuse, major mental disorder and those receiving psychotropic medication will be also excluded.
18 Years
40 Years
ALL
Yes
Sponsors
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University of Nottingham
OTHER
Dr. Najat Khalifa
OTHER
Responsible Party
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Dr. Najat Khalifa
Associate Professor
Principal Investigators
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Najat Khalifa, MD
Role: PRINCIPAL_INVESTIGATOR
Queen's University - Canada
Locations
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Queen's University
Kingston, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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6025821
Identifier Type: -
Identifier Source: org_study_id
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