remedē System Therapy Study

NCT ID: NCT03884660

Last Updated: 2025-07-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

225 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-18

Study Completion Date

2030-12-30

Brief Summary

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The purpose of this non-randomized post market study is to collect clinical data on the safety and effectiveness of the remedē System in a real-world setting.

Detailed Description

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This is a multi-center, prospective, open label, non-randomized study to collect safety and effectiveness data in subjects with central sleep apnea implanted with the remedē System. Approximately 225 subjects will be enrolled and implanted at approximately 50 sites in the United States and Europe. A sub-study involving the WatchPAT device will be performed in a subset of sites.

Conditions

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Central Sleep Apnea

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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remede System

Patients undergoing a remede System implant attempt. Study devices will be used per approved indications for use for each geography.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Moderate to severe central sleep apnea (AHI ≥ 15 events per hour) based on a sleep study scored by a local sleep laboratory. It is strongly recommended that a patient have a diagnostic PSG within 12 months of the expected implant date documenting moderate to severe CSA.
2. Age 18 years or older
3. Signed Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved informed consent
4. In the opinion of the investigator, subject is willing and able to comply with the protocol.
5. Not currently enrolled in another investigational study or registry that would directly interfere with the current study, except if the subject is participating in a mandatory government registry, or a purely observational registry with no associated treatments. Each instance should be brought to the attention of the sponsor to determine eligibility.
6. In the opinion of the Investigator, life expectancy exceeds one year.
7. The subject is not pregnant or planning to become pregnant.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Respicardia, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kathy McPherson

Role: STUDY_DIRECTOR

ZOLL Respicardia, Inc.

Locations

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Banner University Medical Center

Phoenix, Arizona, United States

Site Status

Arizona Heart Rhythm Center

Phoenix, Arizona, United States

Site Status

HonorHealth

Scottsdale, Arizona, United States

Site Status

The University of California San Francisco

San Francisco, California, United States

Site Status

University of Colorado- Anschutz

Aurora, Colorado, United States

Site Status

University of Colorado Health

Fort Collins, Colorado, United States

Site Status

Central Florida Pulmonary Group

Orlando, Florida, United States

Site Status

Emory University Midtown Hospital

Atlanta, Georgia, United States

Site Status

University of Chicago

Chicago, Illinois, United States

Site Status

Baptist Health Lexington

Lexington, Kentucky, United States

Site Status

University of Michigan Health West

Wyoming, Michigan, United States

Site Status

Mayo Clinic

Rochester, Minnesota, United States

Site Status

St. Luke's Mid America Heart Institute

Kansas City, Missouri, United States

Site Status

The Valley Hospital

Paramus, New Jersey, United States

Site Status

New Mexico Heart Institute - Lovelace Medical Center

Albuquerque, New Mexico, United States

Site Status

Northwell Health

New Hyde Park, New York, United States

Site Status

New York Presbyterian Hospital-Weill Cornell Medicine

New York, New York, United States

Site Status

Novant Health - Charlotte

Charlotte, North Carolina, United States

Site Status

East Carolina University

Greenville, North Carolina, United States

Site Status

Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, United States

Site Status

The Ohio State Wexner Medical Center

Columbus, Ohio, United States

Site Status

Ohio Sleep Medicine Institute

Dublin, Ohio, United States

Site Status

Oklahoma Heart Institute

Tulsa, Oklahoma, United States

Site Status

Penn State Health Milton S. Hershey Medical Center

Hershey, Pennsylvania, United States

Site Status

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, United States

Site Status

Thomas Jefferson University

Philadelphia, Pennsylvania, United States

Site Status

Monument Health

Rapid City, South Dakota, United States

Site Status

Baylor Scott and White - Dallas

Dallas, Texas, United States

Site Status

West Virginia University

Morgantown, West Virginia, United States

Site Status

OLVG Amsterdam

Amsterdam, , Netherlands

Site Status

Amphia Longresearch

Breda, , Netherlands

Site Status

Medisch Spectrum Twente

Enschede, , Netherlands

Site Status

Countries

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United States Netherlands

References

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Goldberg LR, Fox H, Stellbrink C, Bozkurt B, Boehmer JP, Mora JI, Doshi R, Morgenthaler TI, Levy WC, Meyer TE, McKane SW, Germany R; remede System Therapy Study Group. Design of the remede System Therapy (reST) study: A prospective non-randomized post-market study collecting clinical data on safety and effectiveness of the remede system for the treatment of central sleep apnea. Sleep Med. 2022 Dec;100:238-243. doi: 10.1016/j.sleep.2022.08.026. Epub 2022 Sep 6.

Reference Type DERIVED
PMID: 36116293 (View on PubMed)

Other Identifiers

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CIP1393

Identifier Type: -

Identifier Source: org_study_id

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