To Compare Intravenous and Oral Hydration of the Prevention for CIN in Elderly Patients Undergoing Intravenous CECT

NCT ID: NCT03872739

Last Updated: 2019-03-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

1368 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-08

Study Completion Date

2021-10-31

Brief Summary

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To Compare Intravenous and Oral Hydration of the Prevention for Contrast-induced Nephropathy in Elderly Patients Undergoing Intravenous Contrast-enhanced Computed Tomography.

Detailed Description

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The prospective multicenter randomized controlled clinical research discusses the comparison of oral and intravenous hydration for prevention of contrast-induced nephropathy in elderly patients with enhanced computed tomography, establishing a simple hydration proposal.

Conditions

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CIN

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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distilled water

Oral distilled water at the rate of 3 mL/kg/h rate during undergoing enhanced computed tomography examination before 1-2 and after 4-6 hours

Group Type EXPERIMENTAL

enhanced computed tomography

Intervention Type PROCEDURE

undergoing enhanced computed tomography

Saline

intravenous saline hydration at the rate of 1 mL/kg/h rate during undergoing enhanced computed tomography examination before and after 12 hours

Group Type PLACEBO_COMPARATOR

enhanced computed tomography

Intervention Type PROCEDURE

undergoing enhanced computed tomography

Interventions

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enhanced computed tomography

undergoing enhanced computed tomography

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age\>21
* informed consent
* Undergoing Intravenous Contrast-enhanced Computed Tomography

Exclusion Criteria

* CT enhancement was not performed;
* Dialysis treatment of patients with end-stage renal failure or heart, kidney transplantation;
* Exposure to radioactive contrast medium within 48 hours prior to or within 72 hours of examination;
* Acute decompensated heart failure;
* Allergic to radioactive contrast agent;
* Be subjected to life - threatening trauma;
* Severe infection;
* Surgery was performed within 2 days of CT examination.
* Combined with multiple myeloma, urinary obstruction, aortic dissection
* Can cause acute kidney injury disease;
* Use of aminoglycosides and other nephrotoxic drugs 2 weeks before.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yu Danqing

OTHER

Sponsor Role lead

Responsible Party

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Yu Danqing

Director,Clinical Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Danqing Yu, Doctor

Role: PRINCIPAL_INVESTIGATOR

Guangdong Cardiovascular Institute

Locations

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Guangdong provincial people's hospital

Guanzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Danqing Yu, Doctor

Role: CONTACT

13631349257

Facility Contacts

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huang jieleng, doctor

Role: primary

Other Identifiers

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201704020124

Identifier Type: -

Identifier Source: org_study_id

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