Contrast Medium Volume and Contrast-induced Nephropathy After Percutaneous Coronary Intervention

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2012-01-31

Brief Summary

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To investigate the predictive value of the contrast media volume to creatinine clearance (V/CrCl) ratio for the risk of contrast-induced nephropathy (CIN) (i.e., within 48-72 h) and to determine a relatively safe V/CrCl cut-off value to avoid CIN in patients following PCI

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Detailed Description

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contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after unselective PCI. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of CIN was assessed using multivariate logistic regression.

Conditions

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Contrast Induced Nephropathy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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percutaneous coronary intervention

The investigators reviewed all consecutive patients who were undergoing percutaneous coronary intervention

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* patients who agreed to stay in the hospital for 2-3 days after percutaneous coronary intervention
* provided written informed consent
* Creatinine Clearance:15-60ml/min

Exclusion Criteria

* pregnancy
* lactation
* intravascular administration of an contrast medium within the previous seven days
* treatment with metformin
* aminoglycosides
* N-acetylcysteine (NAC)
* nonsteroidal anti-inflammatory drugs within the previous 48 h
* intake of nephrotoxic drugs within the previous seven days
* history of serious reactions to contrast mediums
* severe concomitant disease
* renal transplantation , or end-stage renal disease necessitating dialysis patients who died during percutaneous coronary intervention

Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No