Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
168 participants
INTERVENTIONAL
2019-05-03
2021-09-30
Brief Summary
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Detailed Description
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Time-limited cohort study involving serial measurements of Bilateral Anterior Thigh Thickness (BATT) using ultrasound, handgrip strength, physical performance, and physical function measured using the Patient Reported Outcome Measures Information System (PROMIS®). We aim to fully characterise changes in these patients, and will perform a comprehensive evaluation of clinical factors including nutrition and physical activity, and measure immune-endocrine markers of inflammation.
Study Participants
Elective colorectal surgery, emergency abdominal surgery, and medical patients aged 70 years and older
Planned Size of recruitment target
56 elective colorectal patients, 56 emergency abdominal surgery patients, and 56 medical patients with acute infections
Follow up duration
3 months
Primary research question
Does acute change in quadriceps muscle thickness, handgrip strength and/or physical performance within one week of hospitalisation predict change in patient reported physical function at three months?
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Elective colorectal surgery
Patients who are expected to undergo a major colorectal surgery procedure will be recruited to this study preoperatively and followed-up until three months postoperatively.
Colorectal surgery procedure
Elective admission for colorectal surgery
Emergency abdominal surgery
Patients who are admitted as an emergency and undergo abdominal surgery will be recruited from general surgery wards either preoperatively or within 48 hours of surgery. They will be followed-up until three month postoperatively.
Emergency abdominal surgery
Emergency admission necessitating emergency surgery
Medical patients
Patients admitted under general medicine with an infection will be recruited from general medicine wards within 48 hours of admission. They will be followed-up until three month post-admission
Antibiotics
Treatment for infection and reason for admission
Interventions
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Colorectal surgery procedure
Elective admission for colorectal surgery
Emergency abdominal surgery
Emergency admission necessitating emergency surgery
Antibiotics
Treatment for infection and reason for admission
Eligibility Criteria
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Inclusion Criteria
* Aged 70 years or older at time of recruitment
* Expected to undergo an elective major colorectal surgery procedure
EMERGENCY SURGERY COHORT
* Aged 70 years or older at time of recruitment
* Emergency admission
* Expected to undergo emergency abdominal procedure during admission, or emergency abdominal procedure performed within previous 48 hours
MEDICAL COHORT
* Aged 70 years or older at time of recruitment
* Emergency admission for acute bacterial infection or presumed acute bacterial infection
Exclusion Criteria
* Unable to provide written informed consent at time of recruitment
* Unable to understand verbal English
* Life expectancy less than 30 days
EMERGENCY SURGERY COHORT
* Unable to provide written informed consent at time of recruitment and no consultee available
* Unable to understand verbal English
* Life expectancy less than 30 days
MEDICAL COHORT
* Unable to provide written informed consent at time of recruitment and no consultee available
* Unable to understand verbal English
* Life expectancy less than 30 days
70 Years
ALL
No
Sponsors
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Dowager Countess Eleanor Peel Trust
UNKNOWN
University Hospital Birmingham NHS Foundation Trust
OTHER
MRC-Arthritis Research UK Centre for Musculoskeletal Ageing Research
UNKNOWN
University of Birmingham
OTHER
Responsible Party
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Principal Investigators
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Carly Welch, MBChB
Role: STUDY_DIRECTOR
University of Birmingham
Thomas Jackson, MBChB, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Birmingham
Locations
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Queen Elizabeth Hospital Birmingham
Birmingham, West Midlands, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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References
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Welch C, K Hassan-Smith Z, A Greig C, M Lord J, A Jackson T. Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults. Aging Dis. 2018 Feb 1;9(1):151-164. doi: 10.14336/AD.2017.0315. eCollection 2018 Feb.
Welch C, Greig CA, Hassan-Smith ZK, Pinkney TD, Lord JM, Jackson TA. A pilot observational study measuring acute sarcopenia in older colorectal surgery patients. BMC Res Notes. 2019 Jan 14;12(1):24. doi: 10.1186/s13104-019-4049-y.
Welch C, Greig C, Masud T, Jackson TA. Muscle quantity and function measurements are acceptable to older adults during and post- hospitalisation: results of a questionnaire-based study. BMC Geriatr. 2021 Feb 25;21(1):141. doi: 10.1186/s12877-021-02091-3.
Welch C, Greig CA, Masud T, Pinkney T, Jackson TA. Protocol for understanding acute sarcopenia: a cohort study to characterise changes in muscle quantity and physical function in older adults following hospitalisation. BMC Geriatr. 2020 Jul 10;20(1):239. doi: 10.1186/s12877-020-01626-4.
Related Links
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Overall project website (to be updated throughout course of study)
Other Identifiers
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RG_18-213
Identifier Type: -
Identifier Source: org_study_id
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