Reproductive Outcome in Assisted Conception Cycles

NCT ID: NCT03846388

Last Updated: 2023-07-25

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 292 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-02-01
• Study Completion Date: 2022-01-31

Brief Summary

Infertility is the failure to conceive after regular unprotected sexual intercourse for one year. Primary infertility refers woman who has never conceived, and secondary infertility to one who has had a previous pregnancy.The most frequent causes for infertility are ovulatory disorder or anovulation (27-30%) , tubal factor(20-22%), abnormal semen parameters(45-50%). Unexplained infertility refers to infertile couples in whom standard investigations, including tests of ovulation, tubal patency tests and semen analysis are normal. incidence 15-17% of infertile couples. New guidelines on infertility recommend that women with unexplained infertility should be advised for expectant management for 2 years .If pregnancy is not achieved after this period In vitro fertilization Should be considered. The Fast Track and Standard Treatment trial demonstrated A shorter time to pregnancy and higher per cycle pregnancy rates for In vitro fertilization compared with treatment with oral agents or gonadotropins in Patients with unexplained infertility. Successful pregnancy after assisted reproductive technology is influenced by numerous predictors that have been investigated in the previous years. The central predictors of success are the sperm, oocyte quality and endometrial receptivity. Oocyte quality depends mainly on the age of the woman , and her ovarian reserve. Parameters most commonly studied are the woman's age , her antral follicle count , and laboratory tests including serum randomly done during the menstrual cycle levels at day 3 of the cycle.

Conditions

Infertility

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Patients with unexplained infertility

Group Type: OTHER

follicular stimulating hormone

Intervention Type: DIAGNOSTIC_TEST

in the serum of our patients

Anti-mullerian hormone

Intervention Type: DIAGNOSTIC_TEST

in the serum of our patients

Basal antral follicle count

Intervention Type: RADIATION

by ultrasound

patients with tubal, male factor or polycystic ovary syndrome

Group Type: OTHER

follicular stimulating hormone

Intervention Type: DIAGNOSTIC_TEST

in the serum of our patients

Anti-mullerian hormone

Intervention Type: DIAGNOSTIC_TEST

in the serum of our patients

Basal antral follicle count

Intervention Type: RADIATION

by ultrasound

Interventions

follicular stimulating hormone

in the serum of our patients

Intervention Type: DIAGNOSTIC_TEST

Anti-mullerian hormone

in the serum of our patients

Intervention Type: DIAGNOSTIC_TEST

Basal antral follicle count

by ultrasound

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

• in vitro fertilization treatment due to many factors including tubal, male, and unexplained factors.
• body mass index (BMI) (18-35)kg/m2

Exclusion Criteria

1. patient age less than 20 and more than 40 years.

2. body mass index less than 18 and more than 35 kg/m2.

3. period of infertility less than 2 years..

4. untreated hyperthyroidism, hypothyroidism, diabetes, hypertension.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Assiut University

OTHER

Sponsor Role: lead

Responsible Party

Mohammed Khairy Ali

lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Assiut university

Asyut, , Egypt

Countries

Egypt

Other Identifiers

ACC

Identifier Type: -

Identifier Source: org_study_id