LH/HCG Receptor Expression and Retrieval Rates

NCT ID: NCT00438373

Last Updated: 2015-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-31

Study Completion Date

2016-01-31

Brief Summary

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The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up

Detailed Description

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The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG or the day of oocyte retrieval and the retrieval rates at oocyte pick up.

For this purpose, m-RNA copy numbers will be assessed in the blood serum of patients undergoing ovarian stimulation for IVF on different days.

Furthermore, detailed ultrasound scans will be perfomed, as well as assesment of hormonal levels during ovarian stimulation.

Conditions

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Subfertility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age \<39 years,
* Body mass index (BMI) between 18 and 29 kg/m2,
* Presence of both ovaries,
* FSH levels \<10 IU/l.

Exclusion Criteria

* Endometriomas,
* Polycystic ovarian syndrome.
Minimum Eligible Age

18 Years

Maximum Eligible Age

39 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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University of Athens

OTHER

Sponsor Role collaborator

Aristotle University Of Thessaloniki

OTHER

Sponsor Role lead

Responsible Party

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E.M. Kolibianakis

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Basil C Tarlatzis, MD, PhD

Role: STUDY_DIRECTOR

Unit of Human Reproduction, 1st Department of Obs & Gyne, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece

Locations

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Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital

Thessaloniki, , Greece

Site Status

Countries

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Greece

References

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Patsoula E, Loutradis D, Drakakis P, Michalas L, Bletsa R, Michalas S. Messenger RNA expression for the follicle-stimulating hormone receptor and luteinizing hormone receptor in human oocytes and preimplantation-stage embryos. Fertil Steril. 2003 May;79(5):1187-93. doi: 10.1016/s0015-0282(03)00071-2.

Reference Type BACKGROUND
PMID: 12738515 (View on PubMed)

Patsoula E, Loutradis D, Drakakis P, Kallianidis K, Bletsa R, Michalas S. Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos. Reproduction. 2001 Mar;121(3):455-61. doi: 10.1530/rep.0.1210455.

Reference Type BACKGROUND
PMID: 11226072 (View on PubMed)

Other Identifiers

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UHR-1

Identifier Type: -

Identifier Source: org_study_id

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