Study to Examine Effect of Recombinant Luteinizing Hormone (r-Lh) and Recombinant Human Chorionic Gonadotropin (r-hCG) for Ovarian Stimulation in Assisted Reproduction Techniques (ART)

NCT ID: NCT01339299

Last Updated: 2013-11-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2012-07-31

Brief Summary

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The study is a prospective, randomised, controlled, and non-blinded multi-center pilot study to evaluate endocrine efficacy of recombinant luteinizing hormone versus recombinant human chorionic gonadotropin administered during controlled ovarian stimulation for IVF/ICSI in normogonadotrophic women.

Detailed Description

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Conditions

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Controlled Ovarian Stimulation Infertility

Keywords

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COS ART Infertility

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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recombinant luteinizing hormone

150 IU r-LH, recombinant luteinising hormone, from treatment day 1 (stimulation day 1) until day of r-hCG administration (normally treatment day 10 to 14)

Group Type EXPERIMENTAL

recombinant luteinizing hormone (r-LH)

Intervention Type DRUG

administration of r-LH 150 IU/day subcutaneously , from S1 to r-hCG administration day (treatment day 10 to 14)

recombinant human chorionic gonadotrofin

25 IU of r-hCG from treatment day 1 (stimulation day 1) until day of r-hCG administration (normally treatment day 10 to 14 )

Group Type ACTIVE_COMPARATOR

recombinant human chorionic gonadotropin (r-hCG)

Intervention Type DRUG

administration of r-hCG 25 IU/day subcutaneously , from S1 to r-hCG administration day (treatment day 10 to 14)

Interventions

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recombinant luteinizing hormone (r-LH)

administration of r-LH 150 IU/day subcutaneously , from S1 to r-hCG administration day (treatment day 10 to 14)

Intervention Type DRUG

recombinant human chorionic gonadotropin (r-hCG)

administration of r-hCG 25 IU/day subcutaneously , from S1 to r-hCG administration day (treatment day 10 to 14)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Women who plan to undergo IVF or ICSI treatment
* Woman's age \> 18 years but ≤ 35 years
* Regular menstrual cycle (25-34 days)
* BMI 18 to 30 inclusive
* Signed patient information and informed consent forms

Exclusion Criteria

* PCOS
* More than 2 prior IVF/ICSI attempts
* Diabetes mellitus, epilepsy, lever-, kidney-, heart- and metabolism disorders, according to the Investigator's assessment.
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Regionshospitalet Viborg, Skive

OTHER

Sponsor Role lead

Responsible Party

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Peter Humaidan

Prof. M.D. D.M.Sc.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Fertility Clinic Skive regional Hospital

Skive, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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2009-009375-35

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

700642-603

Identifier Type: -

Identifier Source: org_study_id