Biotherapies and Therapeutic Education in Chronic Inflammatory Rheumatism

NCT ID: NCT03838939

Last Updated: 2021-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-21

Study Completion Date

2021-12-10

Brief Summary

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The hypothesis is that group interaction associated with individual interviews intensify the acquisition of safety skills compared to individual interviews alone in patients with CIR treated by subcutaneous biotherapies.

Detailed Description

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Selection and inclusion of patients will be done by principal investigator of Rheumatology Department. After verification of inclusion and non-inclusion criteria by principal investigator and signature of consent, patients will be randomized by 1: 1 randomization (centralized randomization by statistician into 2 groups at M0) :

1. Experimental group (individual and group therapeutic education )

* M0 (individual) Educational diagnosis and biotherapy education: "subcutaneous injection education" and "biotherapy management".
* M3 (group with 3 to 10 patients) Intensification Biotherapy Education: Workshops : "Subcutaneous injection education" and "biotherapy management".
* M6 (individual presential or by phone) Assessment of security skills and questionnaires.
* M12 (individual presential or by phone) Assessment of security skills and questionnaires.
2. Control group (individual therapeutic education alone ) :

* M0 (individual) Educational diagnosis and biotherapy education: "subcutaneous injection education" and "biotherapy management".
* M3 (individual) Intensification Biotherapy Education: "Subcutaneous injection education" and "biotherapy management".
* M6 (individual présential or by phone) Assessment of security skills and questionnaires.
* M12 (individual présential or by phone) Assessment of security skills and questionnaires. Group session proposed.

Conditions

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Rheumatoid Arthritis Spondyloarthritis

Keywords

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chronic inflammatory rheumatism biotherapies therapeutic education safety skills

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

no masking

Study Groups

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interventional group

M3 (group with 3 to 10 patients) Intensification Biotherapy Education Workshops : "Subcutaneous injection education" and "biotherapy management

Group Type EXPERIMENTAL

Therapeutic education

Intervention Type OTHER

Individual and group therapeutic education sessions will consist of :

* acquisition by patient of self-care skills such as performing subcutaneous injection,
* acquisition by patient of safety skills such as identifying symptoms that should lead to consult general practitioner, and stop treatment ...

Control group

M3 (individual) Intensification Biotherapy Education: "Subcutaneous injection education" and "biotherapy management".

Group Type PLACEBO_COMPARATOR

Therapeutic education

Intervention Type OTHER

Individual and group therapeutic education sessions will consist of :

* acquisition by patient of self-care skills such as performing subcutaneous injection,
* acquisition by patient of safety skills such as identifying symptoms that should lead to consult general practitioner, and stop treatment ...

Interventions

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Therapeutic education

Individual and group therapeutic education sessions will consist of :

* acquisition by patient of self-care skills such as performing subcutaneous injection,
* acquisition by patient of safety skills such as identifying symptoms that should lead to consult general practitioner, and stop treatment ...

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient age \> 18 years old with RA (ACR/EULAR criteria) or SA (ASAS criteria) initiating a first subcutaneous biotherapy.
* Patient able to complete a questionnaire
* Patient giving informed consent.
* Patient covered by social security

Exclusion Criteria

* \- Patient with disorder of higher mental function or psychiatric disorders.
* Patient previously treated by intravenous biotherapy.
* Protected populations: pregnant women, breastfeeding women, tutorship, trusteeship, deprived of liberty, safeguard of justice.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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French Society of Rheumatology

OTHER

Sponsor Role collaborator

University Hospital, Clermont-Ferrand

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Françoise FAYET

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Clermont-Ferrand

Locations

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Chu Clermont-Ferrand

Clermont-Ferrand, , France

Site Status

Countries

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France

References

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Gossec L, Fautrel B, Flipon E, Lecoq d'Andre F, Marguerie L, Nataf H, Pallot Prades B, Piperno M, Poilverd RM, Rat AC, Sadji F, Sordet C, Thevenot C, Beauvais C. Safety of biologics: elaboration and validation of a questionnaire assessing patients' self-care safety skills: the BioSecure questionnaire. An initiative of the French Rheumatology Society Therapeutic Education section. Joint Bone Spine. 2013 Oct;80(5):471-6. doi: 10.1016/j.jbspin.2012.11.009. Epub 2013 Aug 20.

Reference Type BACKGROUND
PMID: 23972274 (View on PubMed)

Gronning K, Rannestad T, Skomsvoll JF, Rygg LO, Steinsbekk A. Long-term effects of a nurse-led group and individual patient education programme for patients with chronic inflammatory polyarthritis - a randomised controlled trial. J Clin Nurs. 2014 Apr;23(7-8):1005-17. doi: 10.1111/jocn.12353. Epub 2013 Jul 22.

Reference Type BACKGROUND
PMID: 23875718 (View on PubMed)

Homer D, Nightingale P, Jobanputra P. Providing patients with information about disease-modifying anti-rheumatic drugs: Individually or in groups? A pilot randomized controlled trial comparing adherence and satisfaction. Musculoskeletal Care. 2009 Jun;7(2):78-92. doi: 10.1002/msc.141.

Reference Type BACKGROUND
PMID: 18792423 (View on PubMed)

Koev DJ, Tankova TI, Kozlovski PG. Effect of structured group education on glycemic control and hypoglycemia in insulin-treated patients. Diabetes Care. 2003 Jan;26(1):251. doi: 10.2337/diacare.26.1.251. No abstract available.

Reference Type BACKGROUND
PMID: 12502698 (View on PubMed)

Fayet F, Beauvais C, Pereira B, Beranger M, Rodere M, Pallot-Prades B, Peyrard P, Pouplin S, Grandjean M, Chu Miow Lin D, Ardizzone M, Cherillat MS, Tournadre A, Fan A, Soubrier M. Comparison of group versus individual patient education for promoting safety skills of patients with autoimmune rheumatic diseases treated with biologics: a multicentre randomised controlled trial. Clin Rheumatol. 2025 Jan;44(1):487-494. doi: 10.1007/s10067-024-07218-6. Epub 2024 Nov 5.

Reference Type DERIVED
PMID: 39499437 (View on PubMed)

Other Identifiers

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2018-A00647-48

Identifier Type: OTHER

Identifier Source: secondary_id

CHU-420

Identifier Type: -

Identifier Source: org_study_id