Smoke Inhalation Injury in Patients Admitted to Intensive Care

NCT ID: NCT03834246

Last Updated: 2019-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

700 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-10-16

Study Completion Date

2020-05-31

Brief Summary

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Many Studies have shown that the smoke-inhalation injury is responsible for a high mortality mainly related to the systemic effects of carbon monoxide and cyanide. Respiratory lesions induced by smoke inhalation, is one of predictive factors of mortality.

The aim of the study is to identify the clinical and epidemiological characteristics of smoke-inhalation injury and to identify prognostic factors among these patients .

Detailed Description

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The study is a monocentric, retrospective, descriptive and analytical study , betwen december 1997 and september 2018 in intensive care unit of university of hospital.

All patients aged over 18 year and who had received a diagnosis of smoke- inhalation injury and were admitted to the ICU of Medical University Hospital , a referral center in Paris providing HBO therapy , were potentially eligible for inclusion in this investigation.

Criteria used for recommending HBO therapy to a patient with transient or prolonged unconsciousness, abnormal neurologic findings on physical examination.

Data were analyzed to identify independent factors that may influence mortality.

Conditions

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Smoke Inhalation Injury Morality

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Men or women over the age of 18
* Hyperbaric oxygen therapy between 1997 and 2018

Exclusion Criteria

* Patients under 18 years old.
* Patient opposed to the use of his data
* Patients not treated with hyperbaric oxygen
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre d'Investigation Clinique et Technologique 805

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Rania BOUNAB, dr

Role: PRINCIPAL_INVESTIGATOR

Raymond Poincaré Hospital

Locations

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Raymond Poincaré

Garches, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Rania BOUNAB, Dr

Role: CONTACT

+33 (1) 74 10 7778

Fatima IZEDAREN, CRA

Role: CONTACT

+33 (1) 47 10 44 49

Facility Contacts

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Rania BOUNAB

Role: primary

0698258796

rania Bounab

Role: backup

0147107778

References

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You K, Yang HT, Kym D, Yoon J, HaejunYim, Cho YS, Hur J, Chun W, Kim JH. Inhalation injury in burn patients: establishing the link between diagnosis and prognosis. Burns. 2014 Dec;40(8):1470-5. doi: 10.1016/j.burns.2014.09.015. Epub 2014 Oct 16.

Reference Type BACKGROUND
PMID: 25406889 (View on PubMed)

Kim Y, Kym D, Hur J, Yoon J, Yim H, Cho YS, Chun W. Does inhalation injury predict mortality in burns patients or require redefinition? PLoS One. 2017 Sep 27;12(9):e0185195. doi: 10.1371/journal.pone.0185195. eCollection 2017.

Reference Type BACKGROUND
PMID: 28953914 (View on PubMed)

Darling GE, Keresteci MA, Ibanez D, Pugash RA, Peters WJ, Neligan PC. Pulmonary complications in inhalation injuries with associated cutaneous burn. J Trauma. 1996 Jan;40(1):83-9. doi: 10.1097/00005373-199601000-00016.

Reference Type BACKGROUND
PMID: 8577005 (View on PubMed)

Liao WC, Cheng WC, Wu BR, Chen WC, Chen CY, Chen CH, Tu CY, Hsia TC. Outcome and prognostic factors of patients treated in the intensive care unit for carbon monoxide poisoning. J Formos Med Assoc. 2019 Apr;118(4):821-827. doi: 10.1016/j.jfma.2018.09.005. Epub 2018 Oct 5.

Reference Type BACKGROUND
PMID: 30293927 (View on PubMed)

Raphael JC, Annane D, Chevret S. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 2003 Feb 6;348(6):557-60; author reply 557-60. No abstract available.

Reference Type BACKGROUND
PMID: 12572578 (View on PubMed)

Other Identifiers

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Cicit805

Identifier Type: -

Identifier Source: org_study_id

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