Prevalence of Chronic Pain and Its Risk Factors After a Surgical Intensive Care Unit Stay. Prospective Observational Cohort

NCT ID: NCT04164342

Last Updated: 2022-07-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-11-27
• Study Completion Date: 2022-07-26

Brief Summary

The objective of this observational, prospective study is to evaluate the incidence of chronic pain at 3 months after ICU discharge in patients with a prolonged ICU stay (i.e. ≥3 days).

Investigators will assess the proportion of patients with chronic pain (defined according to the Brief Pain Inventory questionnaire), by interview at 3 months after ICU discharge.

All data potentially associated with chronic pain will be collected, including the type of surgery, the acute pain (intensity and duration) during the ICU stay, the type and dose of opioids received, patients comorbidity...

Patients will be follow-up at 6 and 12 months to identify impact on quality of life.

Detailed Description

Acute pain is common for ICU patients, with an incidence of 33% at rest and of 56% during nursing care. However, there is few if any data on chronic pain after an ICU stay (ie lasting more than 3 months after ICU discharge), while chronic pain seems to be frequent in patients, in particular following surgeries. Indeed, several studies have shown that in postoperative period, many patients suffer from chronic pains, with incidence from 12 to more than 50 %, depending on surgery.

Known risk factors include:

• Female gender
• young age
• mental disorder antecedent
• pain prior to surgery
• type of anesthesia, including the type and dose of opioids used
• not correctly controlled severe pain
• prolonged pain

Chronic pain is becoming a public health problem, because of its impact on patients quality of life, but also on the over consumption of opioids as a result, and the addiction that arise.

Chronic pain following an ICU stay as been studied so far. Available studies in ICU are mainly interested in the quality of life, which remains altered even many years after ICU discharge. The most popular survey is the SF-36 which includes a section on chronic pain. However no study, to the best of our knowledge, were interested in chronic pain prevalence and in its risk factors after an ICU stay.

In our surgical ICU unit, there is two sedation-analgesia protocols, that use different types of opioids (ie sufentanyl or Remifentanyl), in addition physicians may prescribe morphine for awake patients or other oral opioids. The impact of opioid choice on chronic pain prevalence after ICU discharge is not known today, but could be important, as it is for postoperative chronic pain.

We hypothesis that chronic pain is frequent after a surgical ICU stay and that some factors may be associated with it, including the type of opioids received.

The investigators will conduct a prospective observational study to evaluate this prevalence and the risk factors associated with chronic pain following a prolonged ICU stay.

Patients with an ICU stay ≥3 days, capable to answer to questionnaires will be eligible and will be invited to participate to the study just before their discharge from ICU.

After inclusion, patient's conditions prior to ICU stay, type od admission, all critical care events, pain (duration and intensity), treatments (including opioids)... will be collected.

Investigators will pass the Brief Pain Inventory (BPI) questionnaire A to the patients before discharge from ICU.

Investigators will phone the patient at 3 (primary endpoint), 6 and 12 months after ICU discharge, in order to fill BPI questionnaire for chronic pain diagnosis, to evaluate its impact on quality of life, to fill PHQ 2 survey and record all pain treatment. Beside those 3 phone calls, there is no change in patient care, but patients can be offered to consult their doctor in case of chronic pain screening or presence of depressive symptoms.

This study will allow to characterise chronic pain incidence after an hospitalisation period of at least 3 days in surgical ICU, and to better define possible risk factors. Some risk factors of chronic pain could be modifiable, in particular the type of opioid received. Identification of risk factors for chronic pain could help identifying patients who could benefit from specific care or from post-ICU follow-up consultations.

Conditions

Pain, Chronic; Critically Ill; Opioid-Related Disorders

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Single ARM

This is an observational study, all patients will be followed at 3, 6 and 12 months by phone interviews to pass the Brief Pain Inventory (BPI) and the Patient Health Questionnaire-2 (PHQ-2) questionnaires (this is the intervention, since questionnaires at not usually done).

Group Type: EXPERIMENTAL

surveys

Intervention Type: OTHER

Phone interviews to pass the Brief Pain Inventory (BPI) and the Patient Health Questionnaire-2 (PHQ-2) questionnaires (this is the intervention, since questionnaires at not usually done) at 3, 6 and 12 months after ICU discharge.

Interventions

surveys

Phone interviews to pass the Brief Pain Inventory (BPI) and the Patient Health Questionnaire-2 (PHQ-2) questionnaires (this is the intervention, since questionnaires at not usually done) at 3, 6 and 12 months after ICU discharge.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Adult patients
• Hospitalisation in ICU for ≥ 3 days
• Affiliation to French health care coverage
• Oral informed consent of the patient

Exclusion Criteria

• Patient with chronic pain at inclusion :defined as a prescription of pain killers (level 2 or 3), for more than 3 months
• Cancer with life expectancy < 6 months
• Neurological status not allowing to answer surveys
• Pregnant, nursing or parturient women
• Adult deprived of liberty by court judgment or administrative
• Adult patient protected under the law (guardianship)
• Adult with forced psychiatric care

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University Hospital, Angers

OTHER_GOV

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Sigismond SL Lasocki, PU-PH

Role: STUDY_DIRECTOR

University Hospital, Angers

Locations

CHU Angers

Angers, , France

Countries

France

Other Identifiers

2019-A01865-52

Identifier Type: -

Identifier Source: org_study_id