Annexin Imaging in Dissection of the Descending Aorta

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-01

Study Completion Date

2024-12-31

Brief Summary

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The relationship between the presence of a partial thrombus and aortic dilation after type B dissection has recently been reported. The originality lies in the idea of imaging thrombus activity to predict dilation after type B dissection. The innovative character is based on the use of annexin scintigraphy.

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Detailed Description

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To establish the proof of concept in humans of the link between the intensity of 99mTc-annexin V-128 binding in the descending thoracic aorta and the progression of aortic diameter in patients with type B aortic dissection.

Conditions

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Chronic Dissection of Thoracic Aorta (Disorder)

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Annexin

All patients will undergo a 99mTc-annexin V-128 scintigraphy (SPECT)

Group Type EXPERIMENTAL

Annexin

Intervention Type DRUG

All patients will undergo a 99mTc-annexin V-128 scintigraphy (SPECT)

Interventions

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Annexin

All patients will undergo a 99mTc-annexin V-128 scintigraphy (SPECT)

Intervention Type DRUG

Other Intervention Names

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Annexin scintigraphy

Eligibility Criteria

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Inclusion Criteria

* patient whose age is ≥ 18 years old
* any patient seen more than 6 months and less than 5 years after a dissection involving the descending aorta at Bichat Hospital, whether it is a dissection of the descending aorta alone or a dissection of the ascending aorta extended to the descending aorta
* dissection of the uncomplicated descending thoracic aorta: not requiring surgery or stent implantation within the first 6 months after acute dissection
* effective contraception for women of childbearing age

Exclusion Criteria

* scheduled procedure for dissection of the descending aorta
* contraindication to aortic CT with injection of contrast media: renal failure with creatinine clearance \<30 ml/min or creatinine \>200 µmol/l; allergy to contrast media
* history of surgery or stent implantation in the descending thoracic aorta
* pregnant or breastfeeding women
* patient under guardianship or trusteeship
* non affiliation to social security or CMU (beneficiary or assignee)
* patient refusal to participate in the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No