Constitution of ex Vivo Ovarian Tumor Models for the Validation of the Interest of Innovative Therapies and the Search for Tumor or Circulating Biomarkers Predictive of Treatment Response

NCT ID: NCT03831230

Last Updated: 2025-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-07

Study Completion Date

2025-02-27

Brief Summary

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Development of ex vivo models of ovarian cancer, fallopian tubes or peritoneum.

Detailed Description

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Conditions

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Ovarian Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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collection of blood, urine, tumor and ascite samples

collection of blood, urine, tumor and ascite samples during ovarian surgery

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Patient over 18 years old.
* Patient with ovarian cancer, carcinoma of the fallopian tubes, or histologically proven peritoneum. All FIGO stages are accepted for the study.
* Patient to be managed by surgery (laparoscopy and / or laparotomy).

Exclusion Criteria

* Pregnant woman
* Persons deprived of liberty or guardianship (including curatorship)
* History of any other clinically active malignancy in the last 5 years prior to inclusion
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Centre Francois Baclesse

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre François BACLESSE

Caen, , France

Site Status

Countries

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France

References

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Thorel L, Divoux J, Lequesne J, Babin G, Morice PM, Florent R, Desmartin G, Lecouflet L, Marde Alagama C, Leconte A, Clarisse B, Briand M, Rouzier R, Gaichies L, Martin-Francoise S, Le Brun JF, Denoyelle C, Vigneron N, Jeanne C, Blanc-Fournier C, Leman R, Vaur D, Figeac M, Meryet-Figuiere M, Joly F, Weiswald LB, Poulain L, Dolivet E. The OVAREX study: Establishment of ex vivo ovarian cancer models to validate innovative therapies and to identify predictive biomarkers. BMC Cancer. 2024 Jun 7;24(1):701. doi: 10.1186/s12885-024-12429-w.

Reference Type DERIVED
PMID: 38849726 (View on PubMed)

Other Identifiers

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2018-A02152-53

Identifier Type: -

Identifier Source: org_study_id

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