HMB Supplementation in Addition to Multicomponent Exercise in Old Adults
NCT ID: NCT03827499
Last Updated: 2023-05-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
104 participants
INTERVENTIONAL
2019-03-30
2023-04-30
Brief Summary
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Detailed Description
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Thus, the aim of the HEAL study is to assess the effects of the combination of a daily multicomponent exercise and resistance training intervention in addition to HMB supplementation on old adults' health.
The findings of the HEAL study will help professionals from public health systems to identify cost-effectiveness and innovative actions to improve older people's health and quality of life, and endorse exercise practice in older adults living in nursing homes.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Ex-HMB
HMB dietary supplementation and Multicomponent physical exercise program
HMB dietary supplementation
Intervention groups including HMB supplementation (Ex-HMB and NoEx-HMB) will receive a 3 g daily dose of free acid HMB in powder form dissolved freely into 250 mL of water during a 24-week intervention
Multicomponent physical exercise program
Intervention groups including exercise (Ex-HMB and Ex-Plac) will complete an individualized multicomponent training program, five days a week during 24 weeks.
NoEx-HMB
HMB Dietary supplementation
HMB dietary supplementation
Intervention groups including HMB supplementation (Ex-HMB and NoEx-HMB) will receive a 3 g daily dose of free acid HMB in powder form dissolved freely into 250 mL of water during a 24-week intervention
Ex-Plac
Multicomponent physical exercise program
Multicomponent physical exercise program
Intervention groups including exercise (Ex-HMB and Ex-Plac) will complete an individualized multicomponent training program, five days a week during 24 weeks.
Controls
No intervention
No interventions assigned to this group
Interventions
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HMB dietary supplementation
Intervention groups including HMB supplementation (Ex-HMB and NoEx-HMB) will receive a 3 g daily dose of free acid HMB in powder form dissolved freely into 250 mL of water during a 24-week intervention
Multicomponent physical exercise program
Intervention groups including exercise (Ex-HMB and Ex-Plac) will complete an individualized multicomponent training program, five days a week during 24 weeks.
Eligibility Criteria
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Inclusion Criteria
* Be able to follow an active physical rehabilitation program
* Be able to read and wright
* Voluntary participation
* Capable and willing to provide an informed consent
Exclusion Criteria
* Uncontrolled atrial or ventricular arrhythmias
* Aortic dissecting aneurysm
* Severe aortic stenosis
* Acute endocarditis / pericarditis
* Uncontrolled high blood pressure (\>180/100 mmHg)
* Acute thromboembolism
* Acute or severe heart failure
* Acute or severe respiratory failure
* Uncontrolled postural hypotension
* Uncontrolled acute decompensated diabetes mellitus or low blood sugar
* A recent fracture in the last month.
* Coincident participation in any intervention trial
* HMB contraindication, intolerance, or allergy
* Community-dwelling people
* Have regularly performed exercise (\>20 minutes \>3 days/week) in the last 3 months
* Malignant diseases (exceptions: basal or squamous-cell skin carcinoma or carcinoma in situ of the uterine cervix)
* Revascularization within 1 year
* Severe loss of vision, hearing, or communicative ability
* Conditions preventing cooperation
70 Years
ALL
Yes
Sponsors
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Universidad de Murcia
OTHER
Responsible Party
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Javier Courel Ibáñez
Ph.D
Locations
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Faculty of Sport Sciences
Murcia, San Javier, Spain
Countries
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References
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Courel-Ibanez J, Pallares JG; HEAL study group. Effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in addition to multicomponent exercise in adults older than 70 years living in nursing homes, a cluster randomized placebo-controlled trial: the HEAL study protocol. BMC Geriatr. 2019 Jul 5;19(1):188. doi: 10.1186/s12877-019-1200-5.
Other Identifiers
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2131/2018
Identifier Type: -
Identifier Source: org_study_id
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