'Fitness To Fly' Tests In Children With Type II Respiratory Failure
NCT ID: NCT03824223
Last Updated: 2021-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2019-02-01
2021-08-31
Brief Summary
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The study also aims to assess feasibility of a randomised controlled trial (RCT) comparing the standard hypoxic standard test to a modified test designed to better suit children with type two respiratory failure.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
NONE
Study Groups
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new/old HCT component order
new/old hypoxic challenge test (HCT) component order
Where the new test uses pulse oximetry and transcutaneous CO2 monitoring to guide use of ventilatory support and if necessary supplementary oxygen and the old test uses pulse oximetry to titrate supplementary oxygen.
Hypoxic challenge test
Physiological response to 15% ambient oxygen monitored.
old/new HCT component order
old/new hypoxic challenge test (HCT) component order
Where the old test uses pulse oximetry to titrate supplementary oxygen and the new test uses pulse oximetry and transcutaneous CO2 monitoring to guide use of ventilatory support and if necessary supplementary oxygen.
Hypoxic challenge test
Physiological response to 15% ambient oxygen monitored.
Interventions
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Hypoxic challenge test
Physiological response to 15% ambient oxygen monitored.
Eligibility Criteria
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Inclusion Criteria
* Neuromuscular weakness or central hypoventilation
* Established nocturnal or intermittent daytime ventilatory support
Exclusion Criteria
* Cardiac anomaly with right-to-left shunt
0 Years
18 Years
ALL
No
Sponsors
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University College, London
OTHER
Great Ormond Street Hospital for Children NHS Foundation Trust
OTHER
Responsible Party
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Principal Investigators
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Katharine C Pike, PhD
Role: PRINCIPAL_INVESTIGATOR
Great Ormond Street Hospital for Children NHS Foundation Trust
Locations
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Great Ormond Street Hospital for Children NHS Foundation Trust
London, , United Kingdom
Countries
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Other Identifiers
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17IA16
Identifier Type: -
Identifier Source: org_study_id