Post-Approval Study of the TECNIS SYMFONY® Toric Lenses

NCT ID: NCT03791619

Last Updated: 2023-08-29

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

475 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-13

Study Completion Date

2022-08-08

Brief Summary

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This study is a prospective, multicenter, bilateral, non-randomized, open-label, comparative, 6-month clinical study conducted at up to 50 sites in the USA.

Detailed Description

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Conditions

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Cataract Corneal Astigmatism

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Higher Cylinder Toric IOL

Consented subjects that are eligible will have both eyes implanted with a TECNIS Symfony IOL. Each eye may have a different TECNIS Symfony IOL implanted, as determined by the surgeon and the TECNIS Symfony Toric IOL calculator; however, at least one eye must be implanted with either a Symfony Toric IOL Model ZXT150 (lower-cylinder group) or a Model ZXT300 or ZXT375 (higher-cylinder group) and the fellow eye must have the same or a lower toric power. The eye with the highest toric power IOL will determine the model group.

Group Type ACTIVE_COMPARATOR

Higher Cylinder Toric IOL

Intervention Type DEVICE

Symfony Toric models ZXT300 and ZXT375 IOL

Lower Cylinder Toric IOL

Consented subjects that are eligible will have both eyes implanted with a TECNIS Symfony IOL. Each eye may have a different TECNIS Symfony IOL implanted, as determined by the surgeon and the TECNIS Symfony Toric IOL calculator; however, at least one eye must be implanted with either a Symfony Toric IOL Model ZXT150 (lower-cylinder group) or a Model ZXT300 or ZXT375 (higher-cylinder group) and the fellow eye must have the same or a lower toric power. The eye with the highest toric power IOL will determine the model group.

Group Type ACTIVE_COMPARATOR

Lower Cylinder Toric IOL

Intervention Type DEVICE

Symfony Toric model ZXT150 IOL

Interventions

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Higher Cylinder Toric IOL

Symfony Toric models ZXT300 and ZXT375 IOL

Intervention Type DEVICE

Lower Cylinder Toric IOL

Symfony Toric model ZXT150 IOL

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* be at least 22 years old
* have cataracts in both eyes
* have a certain degree of astigmatism in at least one eye
* sign the written informed consent
* be willing and able to comply with examination procedures
* understand, read and write English to complete informed consent and questionnaires
* be available for study follow-up visits

Both eyes must qualify to be eligible to participate in the study

Exclusion Criteria

* Currently participating in any other clinical study or have participated in a clinical study during the last 30 days
* Have a certain disease/illness such as poorly-controlled diabetes
* Have certain ocular conditions such as uncontrolled glaucoma
* Taking medication that may affect subject vision
* Have irregular corneal astigmatism
* Pregnant, plan to become pregnant during the study, or is breastfeeding
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johnson & Johnson Surgical Vision, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Johnson & Johnson Surgical Vision Clinical Trials

Role: STUDY_DIRECTOR

Johnson & Johnson Surgical Vision

Locations

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Empire Eye & Laser Center

Bakersfield, California, United States

Site Status

Southern California Eye Physicians & Associates

Long Beach, California, United States

Site Status

Santa Monica Eye Medical Group

Santa Monica, California, United States

Site Status

Wolstan & Goldberg Eye Associates

Torrance, California, United States

Site Status

Florida Eye Microsurgical Institute, Inc.

Boynton Beach, Florida, United States

Site Status

The Eye Associates of Manatee

Bradenton, Florida, United States

Site Status

Levenson Eye Associates

Jacksonville, Florida, United States

Site Status

North Florida Eye Surgeons, LLC dba Florida Eye Specialist

Jacksonville, Florida, United States

Site Status

Center For Sight

Sarasota, Florida, United States

Site Status

Virdi Eye Clinic & Laser Vision Care

Rock Island, Illinois, United States

Site Status

Chesapeake Eye Care & Laser

Annapolis, Maryland, United States

Site Status

Oakland Ophthalmic Surgery

Birmingham, Michigan, United States

Site Status

Tekwani Vision Center

St Louis, Missouri, United States

Site Status

Northern New Jersey Eye Institute PA

South Orange, New Jersey, United States

Site Status

Ludwick Eye Center

Chambersburg, Pennsylvania, United States

Site Status

Carolina Cataract & Laser Center

Ladson, South Carolina, United States

Site Status

Vance Thompson Vision

Sioux Falls, South Dakota, United States

Site Status

Memphis Eye & Cataract Associates, PLLC

Memphis, Tennessee, United States

Site Status

Cornea Associates of Texas

Dallas, Texas, United States

Site Status

Texas Eye & Laser Center

Hurst, Texas, United States

Site Status

Focal Point Vision

San Antonio, Texas, United States

Site Status

Parkhurst NuVision

San Antonio, Texas, United States

Site Status

Clarus Eye Centre

Lacey, Washington, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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TIOL-205-STPA

Identifier Type: -

Identifier Source: org_study_id

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