The Association of Cardiac Ion Channel Related Gene Polymorphism and Prolonged QTc Interval After Endotracheal Intubation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

315 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-09-24

Study Completion Date

2020-05-03

Brief Summary

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The QTc interval is affected by heart rate, medications and changes in the autonomic nervous system. The endotracheal laryngoscopy, the necessary step during general anesthesia, prolongs QTc interval. Changes in the flow of ion currents could result from the genetic variation of myocardial ion channels by gene polymorphism. This study is to investigate the association of cardiac ion channel related gene polymorphism and prolonged QTc interval after endotracheal intubation in adult patients.

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Detailed Description

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Conditions

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Emergence Delirium

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

1. 20-65 years old
2. scheduled for general anesthesia requiring direct laryngoscopy

Exclusion Criteria

1. Patients taking antihypertensive medication (beta-blocker, CCB)
2. patients taking other medications known to affect QTc interval
3. Patients with abnormal ECG and prolonged QTc (\>500 msec)
4. Diabetes, liver disease, kidney disease, heart failure, congenital heart disease
5. Severe electrolyte imbalance
6. illiterate, foreigners who cannot understand the consent form

Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes