Reducing Pain in Emergency Department by Using Veinous Blood Gas Instead of Arterious Blood Gas

NCT ID: NCT03784664

Last Updated: 2019-06-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-20

Study Completion Date

2019-03-22

Brief Summary

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Blood gases are widely used in emergency and resuscitation services and are the key examination for exploring acid-base balance disorders (using pH, PaCO2 and HCO3 ) and gas exchange disorders (using PaO2 and PaCO2). This examination can be taken from both venous and arterial sample and its analysis depends on the type of blood sample. Currently, several studies have already shown the existence of a good correlation of pH and bicarbonates level between a venous and arterial sample. Thus, when this examination is prescribed for the purpose of highlighting and analyzing an acid-base disorder, venous blood gas is theoretically as efficient as arterial blood gas.

Due to the lack of evidence of benefit for the patient or the health care team of a venous blood gas rather than an arterial blood gas in the absence of suspicion of hypoxemia, arterial blood gas is currently the standard of care for the analysis of acid-base disorders. Indeed, among the university hospitals affiliated to the Paris Diderot University, the emergency departments carry out in their vast majority (4 of 5 E.D.) arterial blood gases. Demonstration of the superiority of veinous sample over arterial sample regarding pain could substantially modify current practices.

The investigator's main hypothesis is that, in the absence of suspicion of hypoxemia (normal oxygen saturation measured by plethysmography), the realization of a venous blood gas for the evaluation of the acid-base balance in the context of emergencies is less painful for patients, simpler for the health care team and provides sufficient biochemical information for the doctor in comparison with an arterial blood gas.

Detailed Description

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Conditions

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Acid Base Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Arterial blood gas

Group Type ACTIVE_COMPARATOR

Arterial blood gas

Intervention Type DIAGNOSTIC_TEST

arterial blood sample with puncture of the radial artery

Veinous blood gas

Group Type EXPERIMENTAL

Veinous blood gas

Intervention Type DIAGNOSTIC_TEST

veinous blood sample using peripheral venepuncture

Interventions

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Arterial blood gas

arterial blood sample with puncture of the radial artery

Intervention Type DIAGNOSTIC_TEST

Veinous blood gas

veinous blood sample using peripheral venepuncture

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* necessity of blood gas analysis
* age \> 18 yo
* SpO2\>95% without supplemental oxygen
* no altered level of consciousness: Glasgow Coma Scale=15

Exclusion Criteria

* Patient under guardianship or curatorship
* confusional state or patient unable to understand the protocol
* no social security
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Damien Roux, MD,PhD

Role: STUDY_CHAIR

Intensive care department, Louis Mourier hospital

Locations

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Hôpital Beaujon

Clichy, , France

Site Status

Hôpital Louis Mourier

Colombes, , France

Site Status

Hôpital Lariboisière

Paris, , France

Site Status

Hôpital Bichat

Paris, , France

Site Status

Countries

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France

References

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Chauvin A, Javaud N, Ghazali A, Curac S, Altar A, Ali T, Beguin N, Bellier J, Coupier A, Delsarte L, Dreyfuss D, Kheirbek N, Oudar C, Stordeur Y, Weiss M, Gaudry S, Lambert J, Roux D. Reducing pain by using venous blood gas instead of arterial blood gas (VEINART): a multicentre randomised controlled trial. Emerg Med J. 2020 Dec;37(12):756-761. doi: 10.1136/emermed-2019-209287. Epub 2020 Aug 5.

Reference Type DERIVED
PMID: 32759347 (View on PubMed)

Other Identifiers

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Assistance Publique - Hôpitaux

Identifier Type: -

Identifier Source: org_study_id

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