Role of the Peritoneal Microenvironment in the Pathogenesis and Spread of Colorectal Carcinomatosis

NCT ID: NCT03777943

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

53 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-11-01

Study Completion Date

2022-03-28

Brief Summary

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The goal of this project is to investigate the extent and role of mesothelial - mesenchymal transition (MMT) and cancer associated fibroblasts (CAFs) in the pathogenesis of colorectal peritoneal carcinomatosis (PC).

Detailed Description

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Conditions

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Peritoneal Carcinomatosis

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Cytoreductive surgery (CRS)

In patients presenting with colorectal peritoneal carcinomatosis, peritoneal tissue will be sampled during surgery at 4 different locations.

Sampling peritoneal tissue

Intervention Type PROCEDURE

Resection specimen will be obtained during CRS from normal peritoneum at a distance, normal peritoneum close to a peritoneal metastasis, miliary peritoneal carcinomatosis, and established peritoneal carcinomatosis.

Interventions

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Sampling peritoneal tissue

Resection specimen will be obtained during CRS from normal peritoneum at a distance, normal peritoneum close to a peritoneal metastasis, miliary peritoneal carcinomatosis, and established peritoneal carcinomatosis.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

• Patients presenting with colorectal peritoneal carcinomatosis

Exclusion Criteria

* Pregnancy or breast feeding
* Psychiatric pathology capable of affecting comprehension and judgment faculty
* HIPEC (hyperthermic intraperitoneal chemotherapy) or PIPAC (pressurized intraperitoneal aerosol chemotherapy) in the past
* Abdominal radiation treatment
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Ghent

OTHER

Sponsor Role collaborator

Belgian Federation Against Cancer

OTHER

Sponsor Role collaborator

University Hospital, Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ghent University Hospital

Ghent, , Belgium

Site Status

Countries

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Belgium

Other Identifiers

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EC/2017/0784

Identifier Type: -

Identifier Source: org_study_id

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