The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery

NCT ID: NCT03761576

Last Updated: 2022-10-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2018-12-21
• Study Completion Date: 2023-10-31

Brief Summary

The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

Detailed Description

Patients after surgery are liable to suffer from moderate to severe acute pain and refractory chronic pain, which would lead to serious somatic and psychological suffering. Its successful treatment is a great challenge for pain physicians. To date, the mechanism of pain chronification after surgery remains unclear. Further, it is still lack of efficient preventive and therapeutic measures for this chronic pain. The project will apply the methods of clinical observation and animal experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after thoracic surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after thoracic surgery. The project will be able to determine the relationships between the degree of recovery of early postoperative cognitive function, as well as preoperative resting-state EEG indices and postoperative acute pain and chronic pain, and clarify the neural mechanism of acute pain and chronic pain after surgery. The expected outcomes of this study can contribute to early identification of the patients who are liable to develop into acute pain and chronic pain after surgery, and give them reasonable intervention in time, and provide effective solutions for the acute pain and chronic pain after surgery.

Conditions

Acute Pain; Chronic Pain; Thoracic Surgery; Electroencephalography; Brain Mechanism

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• surgery were planned to be performed under general anesthesia
• Educational attainment beyond high school
• Require postoperative analgesia and sign the informed consent

Exclusion Criteria

• with mental illness or a family history of mental illness
• Patients with cerebrovascular diseases or cerebrovascular accidents
• Previous head trauma history or craniotomy
• Using central analgesics, opioids addiction
• With a history of alcoholism
• do not understand the numerical rating scale(NRS) score and can not use patient-controlled analgesia(PCA）

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Yi Feng, MD

OTHER

Sponsor Role: lead

Responsible Party

Yi Feng, MD

director of department of anesthesiology and painmanagement

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Yi Feng, MD

Role: STUDY_CHAIR

Peking University People's Hospital

Locations

Peking University People's Hospital

Beijing, Beijing Municipality, China

Countries

China

References

Zhang YQ, Li YR, Han Q, Gao F, Feng Y. Evaluation of dynamic brain function in patients with different degrees of chronic pain by EEG microstate analysis. BMC Anesthesiol. 2025 Oct 14;25(1):491. doi: 10.1186/s12871-025-03326-1.

Reference Type: DERIVED

PMID: 41087907 (View on PubMed)

Han Q, Yue L, Gao F, Zhang L, Hu L, Feng Y. The Prediction of Acute Postoperative Pain Based on Neural Oscillations Measured before the Surgery. Neural Plast. 2021 Apr 9;2021:5543974. doi: 10.1155/2021/5543974. eCollection 2021.

Reference Type: DERIVED

PMID: 33897775 (View on PubMed)

Other Identifiers

2018PHB191-02

Identifier Type: -

Identifier Source: org_study_id