Effect of Lidocaine in Antiarrhythmic Dosage on Postoperative Cognitive Dysfunction in Supratentorial Craniotomy Dysfunction in Supratentorial Craniotomy
NCT ID: NCT00975910
Last Updated: 2013-05-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
100 participants
INTERVENTIONAL
2009-09-30
2012-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Saline
saline
Saline arm: infused at the same rate as lidocaine
Lidocaine
lidocaine
Lidocaine arm: lidocaine (2%) as an intravenous bolus (1.5 mg/kg) during induction followed by an intravenous infusion (2 mg. kg(-1).h(-1)) after induction until at the end of surgery
Interventions
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lidocaine
Lidocaine arm: lidocaine (2%) as an intravenous bolus (1.5 mg/kg) during induction followed by an intravenous infusion (2 mg. kg(-1).h(-1)) after induction until at the end of surgery
saline
Saline arm: infused at the same rate as lidocaine
Eligibility Criteria
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Inclusion Criteria
* Scheduled for elective supratentorial craniotomy
* MMSE\<24 before operation
* Cooperative and given informed consent in person
Exclusion Criteria
* Contraindicated to internal jugular venous catheterization
* Pregnant or lactating female
* History of systemic malignant tumor or diabetes
* Previously treated with this protocol or participated in another study within previous 30 days
* Suspected history of allergic reaction or intolerance to amides or other anesthetic agents in this study
* History of alcohol abuse and/or drug abuse within previous one year
* History or a family history of malignant hyperthermia
18 Years
60 Years
ALL
No
Sponsors
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State University of New York - Downstate Medical Center
OTHER
Capital Medical University
OTHER
Responsible Party
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Wei Zhang
attending
Locations
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Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
Countries
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Other Identifiers
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20090801
Identifier Type: -
Identifier Source: org_study_id
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