Evaluation of the Biop Colposcopy System's Safety and Performance (Accuracy of Its Registration Procedure)

NCT ID: NCT03750214

Last Updated: 2020-01-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

26 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-05-31

Study Completion Date

2020-12-31

Brief Summary

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This is a multi-center, prospective, non-randomized, confirmatory study to evaluate the safety and performance of the Biop Digital Colposcope and the accuracy of the image registration procedure between the Biop Digital Colposcope unit and the Biop Micro Colposcope probe unit.

Detailed Description

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This is a multi-center, prospective, non-randomized, confirmatory study to evaluate the safety and performance of the Biop Digital Colposcope and the accuracy of the image registration procedure between the Biop Digital Colposcope unit and the Biop Micro Colposcope probe unit.

The Biop Digital Colposcope is intended for magnified viewing of the tissues of the vagina, cervix and external genitalia in order to assist doctors in diagnosing abnormalities such as lesions or cancer, and selecting areas for biopsy. The images from the digital colposcope are to be viewed on a color display. The digital colposcope is intended for use in hospitals, clinics, and doctor's offices.

The Biop Micro Colposcope probe unit is an imaging tool intended to be placed in the vagina for acquisition of images of the cervix. It is intended as an adjunct to the Biop Digital Colposcope. It should NOT be used as a substitute for a thorough colposcopic evaluation. The Biop Micro Colposcope Probe unit is not intended for use on the vulva and vagina.

It is anticipated that it will take approximately 3 months to complete active enrollment. Study duration for each subject is 1-2 days, including screening, enrolment and procedure. The study will be completed when the final study subject has completed the procedure.

1. Performance - to confirm that average image registration error is less than or equal to (≤) 2mm.
2. Safety - to evaluate the safety of the Biop Digital Colposcope in women undergoing cervical colposcopy procedures.

Conditions

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Cervical Cancer Screening

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Biop Coplposcopy System

Biop Colposcopy system procedure

Group Type EXPERIMENTAL

Biop Colposcopy System

Intervention Type DEVICE

The procedure stages:

1. Scanning of the cervix - the cervix is scanned using the micro colposcope probe unit, to produce a total of 51 micro-images and one macro image from the panoramic camera.
2. Colposcopy exam - during the standard colposcopy exam, the doctor acquires a panoramic image of the cervix with the digital colposcope.
3. A questionnaire completed by the subject after the Biop procedure, with regards to any unusual sensations or events experienced during the procedure.
4. A questionnaire completed by the user after the Biop procedure, with regards to system usage
5. Image Registration analysis

Interventions

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Biop Colposcopy System

The procedure stages:

1. Scanning of the cervix - the cervix is scanned using the micro colposcope probe unit, to produce a total of 51 micro-images and one macro image from the panoramic camera.
2. Colposcopy exam - during the standard colposcopy exam, the doctor acquires a panoramic image of the cervix with the digital colposcope.
3. A questionnaire completed by the subject after the Biop procedure, with regards to any unusual sensations or events experienced during the procedure.
4. A questionnaire completed by the user after the Biop procedure, with regards to system usage
5. Image Registration analysis

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Females, ages 22 to 65 years old
* Referred for colposcopy, following abnormal cervical cytology
* Subject provides signed informed consent

Exclusion Criteria

* Currently pregnant or nursing
* Currently menstruating
* Currently has intrauterine device (IUD)
* Diagnosed with diseases that may influence the color of the tissue, e.g., hepatitis, polycytemia vera.
* Diagnosed with pathologies that affect blood coagulation, the immune system or undergoing any treatment that interfere with coagulation or the immune system
* HIV-positive status
* Psychological instability, inappropriate attitude or motivation
* Use of any additional experimental drug or device or participation in another clinical study within the past 30 days
Minimum Eligible Age

22 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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BIOP Medical

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ram Eitan, Md.

Role: PRINCIPAL_INVESTIGATOR

RMC Israel

Central Contacts

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Dana Raveh Arbel

Role: CONTACT

972528591891

Other Identifiers

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CLP - 430

Identifier Type: -

Identifier Source: org_study_id

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