RCTrial to Test Low Intensity Shockwave Treatment in Patients With Mild/Moderate Erectile Dysfunction

NCT ID: NCT03741439

Last Updated: 2018-11-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-17

Study Completion Date

2019-01-02

Brief Summary

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Even though, the efficacy of Low-Intensity Shockwave Therapy (LIST) to treat Erectile Dysfunction (ED) has been documented by numerous trials; it is still not recommended by clinical guidelines. Different types of: shockwave generators, treatment protocols and ED severities of patients included in the studies, explain the lack of recommendations for a standard treatment. Ideally, each shockwave generator should have its own efficacy data from randomized controlled trials, using standardized protocols, and in defined populations.

Objective: to test the efficacy of a electromagnetic shockwave generator (Dornier Aries) in treating patients with mild and moderate ED in a randomized controlled trial.

Patients and methods: 38 patients with mild/moderate ED (IIEF-5= 11-21), are being prospectively randomized (1:1) to receive 6 sessions of LIST or sham (same: number of sessions, time and sound, with out transmitting energy). The patients and who analyzed the data are blind to randomization. The following parameters were analyzed: IIEF-5, IIEF-15, Sexual Encounter Profile (SEP) 2 and 3, Global Assessment Question (GAQ) 1 and Erection Hardness Score (EHS) at: baseline (T0), at the end of the 6 sessions (T1); at 6 (T2) and 12 weeks (T3). During all the study patients were instructed to receive no other treatment for ED.

After ending T3 we expect to treat placebo patients to see impact of changing arm study.

Detailed Description

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We are test the efficacy of a electromagnetic shockwave generator (Dornier Aries) in treating patients with mild and moderate ED in a randomized controlled trial.

Patients and methods: 38 patients with mild/moderate ED (IIEF-5= 11-21), are being prospectively randomized (1:1) to receive 6 sessions of LIST or sham (same: number of sessions, time and sound, with out transmitting energy). The patients and who analyzed the data are blind to randomization. The following parameters were analyzed: IIEF-5, IIEF-15, Sexual Encounter Profile (SEP) 2 and 3, Global Assessment Question (GAQ) 1 and Erection Hardness Score (EHS) at: baseline (T0), at the end of the 6 sessions (T1); at 6 (T2) and 12 weeks (T3). During all the study patients were instructed to receive no other treatment for ED.

After ending T3 we expect to treat placebo patients to see impact of changing arm study.

Conditions

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Erectile Dysfunction Endothelial Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized controlled trial
Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors
Patients and who analyzes the data are blind to randomization.

Study Groups

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Treatment arm

Receives real treatment according to manufactures instructions. 6 sessions of low intensity shockwave treatment with an electromagnetic emitter.

Group Type EXPERIMENTAL

Treatment

Intervention Type DEVICE

Low intensity shockwave treatment in patients with mild/moderate ED using a electromagnetic emitter

Sham Arm

Receives sham treatment with same applicator, same sound, same time and number of shocks. But no real energy is delivered.

Group Type SHAM_COMPARATOR

Sham

Intervention Type DEVICE

Sham treatment

Interventions

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Treatment

Low intensity shockwave treatment in patients with mild/moderate ED using a electromagnetic emitter

Intervention Type DEVICE

Sham

Sham treatment

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Mild/moderate erectile dysfunction
* Good response to any phospodiesterase inhibitor

Exclusion Criteria

* No history of erectile dysfunction
* No decompensated diabetes
* No untreated hypogonadism
* No severe erectile dysfunction
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Pontificia Universidad Catolica de Chile

OTHER

Sponsor Role collaborator

University of Chile

OTHER

Sponsor Role collaborator

IVI Santiago de Chile

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marcelo Marconi, MD

Role: PRINCIPAL_INVESTIGATOR

Asistant Professor Urology Department Universidad Catolica de Chile

Locations

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Unidad de Andrologia - Red Salud UC/Christus

Santiago, Santiago Metropolitan, Chile

Site Status RECRUITING

Countries

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Chile

Central Contacts

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Marcelo Marconi, MD

Role: CONTACT

+56979685115

Marcelo Marconi, MD

Role: CONTACT

+56979685115

Facility Contacts

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Marcelo Marconi, MD

Role: primary

+56979685115

Marcelo Marconi, MD

Role: backup

+56979685115

Other Identifiers

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Marconi01

Identifier Type: -

Identifier Source: org_study_id

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