Low-Intensity Extracorporeal Shockwave Therapy and Vacuum Erectile Device as a Treatment for Peyronies Disease.

NCT ID: NCT03530540

Last Updated: 2019-03-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-03-13

Study Completion Date

2020-02-01

Brief Summary

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Aim The primary aim is to examine whether LI-ESWT and vacuum erectile device (VED) followed by manipulation exercises has beneficial effect on PD patients compared to a placebo group.

Primary Outcome

* Peyronie's Disease Questionnaire (PDQ)
* Visual Analogue Scale score (VAS)
* International Index of Erectile Function 5 (IEFF-5)
* Penile curve measurements (gold standard) on pictures before and after treatment
* Plaque size

Method This study is designed as a prospective, randomized, double-blinded, placebo-controlled with follow-up after 1, 3 and 6 months.

A total of 50 participants who meets the inclusion criteria's will randomly be assigned to I(intervention) or C(control) group based on a randomization list which is retained in a sealed envelope. The content of the envelope is only familiar to the Head of the Department of Urology to ensure valid randomization.

All treatment sessions are executed at the outpatient clinic of the department of urology department L at Odense University Hospital(OUH). All patients receive treatment with the same device a Duolith® SD1 T-Top from Storz Medical. However, when treating patients in the control group the handpiece will be covered by a shockwave absorbent material. Settings and setup are identical in both groups to make sure that patients are unable to acknowledge which treatment is being performed.

Detailed Description

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Conditions

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Peyronie Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Intervention

Active shockwaves

Group Type EXPERIMENTAL

low-intensity extracorporeal shockwave therapy

Intervention Type DEVICE

Active shockwaves

Penile pump

Intervention Type DEVICE

both groups will be treated with a penile pump

Placebo

Placebo shockwaves

Group Type PLACEBO_COMPARATOR

Placebo LI-ESWT

Intervention Type DEVICE

Placebo shockwaves

Penile pump

Intervention Type DEVICE

both groups will be treated with a penile pump

Interventions

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low-intensity extracorporeal shockwave therapy

Active shockwaves

Intervention Type DEVICE

Placebo LI-ESWT

Placebo shockwaves

Intervention Type DEVICE

Penile pump

both groups will be treated with a penile pump

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* PD for more than 6 months
* Penile curve greater than 30 degrees and less than 90 degrees
* Age 18-80
* No previous penile surgery
* Informed consent
* Able to speak and understand Danish

Exclusion Criteria

* Penile curve greater than 90 degrees
* Previous surgery for PD
* Patients undergoing other interventions for PD
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Odense University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lars Lund,MD

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Odense university hospital

Odense, , Denmark

Site Status RECRUITING

Countries

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Denmark

Facility Contacts

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Lars Lund, Professor

Role: primary

45 5140 8982

Other Identifiers

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20170201

Identifier Type: -

Identifier Source: org_study_id

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