Low-energy Linear Extracorporal Shock Wave Therapy for Erectile Dysfunction.

NCT ID: NCT02063061

Last Updated: 2016-12-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

126 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-02-28

Study Completion Date

2015-12-31

Brief Summary

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The purpose of this study is to determine whether extracorporeal shock wave therapy (ESWT) is an effective treatment for erectile dysfunction.

Detailed Description

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Erectile dysfunction has a negative impact on quality of life and relationships. Thirty to sixty- five percent of men over 40 years of age have erection disorders. Current challenges of medical treatment are met with high costs and risks of side effects. Emerging new therapy with low-energy shock waves stimulate production of endothelial growth factor and nitrogen oxide which results in angiogenesis. It is our aim to assess efficaciousness of this method on potential to improve erectile dysfunction. We propose a prospective double-blind, randomised, cross-over, sham-controlled trial, to assess how effective shock waves therapy is for erectile dysfunction. Patients will receive one treatment per week for ten weeks. Subjects will be followed for up to one year after treatment. Standardized questionnaires will assess study endpoints for erectile dysfunction. We hypothesize that shock wave therapy could represent a low cost, low risk treatment for erectile dysfunction in men.

Conditions

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Erectile Dysfunction

Keywords

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extracorporeal shock wave therapy ESWT erectile dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Sham treatment

Subject will answer standardized questionnaires. Sham treatment arm will receive initially 5 sham series and after they answer standardized questionnaires they will receive 5 series of active treatment. Afterwards patients will answer standardized questionnaires again.

Group Type SHAM_COMPARATOR

Sham treatment

Intervention Type DEVICE

Patients will receive simulated treatment, with the same ESWT unit as in other arm. Placebo gel-pad is design to prevent shockwaves emission. Looks identical as active gel-pad.

ESWT treatment

Intervention Type DEVICE

ESWT treatment group will receive 600 low-energy, linear shockwaves against erectile dysfunction per week in 10 weeks.

ESWT treatment

Subject will answer standardized questionnaires. Subjects will receive 10 treatments with ESWT. Afterwards patients will answer standardized questionnaires again.

Group Type ACTIVE_COMPARATOR

ESWT treatment

Intervention Type DEVICE

ESWT treatment group will receive 600 low-energy, linear shockwaves against erectile dysfunction per week in 10 weeks.

Interventions

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Sham treatment

Patients will receive simulated treatment, with the same ESWT unit as in other arm. Placebo gel-pad is design to prevent shockwaves emission. Looks identical as active gel-pad.

Intervention Type DEVICE

ESWT treatment

ESWT treatment group will receive 600 low-energy, linear shockwaves against erectile dysfunction per week in 10 weeks.

Intervention Type DEVICE

Other Intervention Names

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Sham ESWT

Eligibility Criteria

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Inclusion Criteria

* Erectile dysfunction for at least 6 months
* In relationships
* Patient accept not to use any other therapy against erectile dysfunction

Exclusion Criteria

* Prostatectomy
* Radiotherapy in pelvis
* Hormonal therapy against prostate cancer
* Anatomical penis disorder
* Penile prosthesis
* Treatment with anticoagulants (except acetylsalicylic acid 75 mg)
* Psychiatric disorder
* Hypogonadism
* IIEF score higher than 25
* Pregnant partner og delivered within last 12 months
* Critical health disease
* Neurological disorders
Minimum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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University of Southern Denmark

OTHER

Sponsor Role collaborator

Region of Southern Denmark

OTHER

Sponsor Role collaborator

Grzegorz Fojecki

OTHER

Sponsor Role lead

Responsible Party

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Grzegorz Fojecki

MD

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Palle Oshter, professor

Role: STUDY_DIRECTOR

University of Southern Denmark

Locations

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Hospital of Southern Denmark

Sønderborg, Southern Denmark, Denmark

Site Status

Countries

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Denmark

References

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Gruenwald I, Appel B, Kitrey ND, Vardi Y. Shockwave treatment of erectile dysfunction. Ther Adv Urol. 2013 Apr;5(2):95-9. doi: 10.1177/1756287212470696.

Reference Type RESULT
PMID: 23554844 (View on PubMed)

Gruenwald I, Appel B, Vardi Y. Low-intensity extracorporeal shock wave therapy--a novel effective treatment for erectile dysfunction in severe ED patients who respond poorly to PDE5 inhibitor therapy. J Sex Med. 2012 Jan;9(1):259-64. doi: 10.1111/j.1743-6109.2011.02498.x. Epub 2011 Oct 18.

Reference Type RESULT
PMID: 22008059 (View on PubMed)

Vardi Y, Appel B, Jacob G, Massarwi O, Gruenwald I. Can low-intensity extracorporeal shockwave therapy improve erectile function? A 6-month follow-up pilot study in patients with organic erectile dysfunction. Eur Urol. 2010 Aug;58(2):243-8. doi: 10.1016/j.eururo.2010.04.004. Epub 2010 May 6.

Reference Type RESULT
PMID: 20451317 (View on PubMed)

Related Links

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http://www.sdu.dk/

University of Southern Denmark

Other Identifiers

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CIV-13-07-011546

Identifier Type: -

Identifier Source: org_study_id