Mechanisms of Change in Brief Treatment for Borderline Personality Disorder

NCT ID: NCT03717818

Last Updated: 2018-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-19

Study Completion Date

2022-12-31

Brief Summary

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The present two-arm randomized controlled study aims at testing the effects (i.e., symptom reduction) and the underlying mechanisms of change associated with a brief psychiatric treatment (10 sessions over 4 months), compared with treatment as usual. Participants undergo assessments at four points (intake, 2 months, discharge and 12 month follow-up). In addition to symptom measures, all individuals undergo a two-step assessment for the potential mechanisms of change (i.e., emotion and socio-cognitive processing): a) behavioural and b) neurofunctional. We hypothesize that change in the mechanisms explains the treatment effects. The present study uses an innovative treatment of BPD and at the same time a sophisticated assessment procedure to demonstrate the critical role of psychobiological change in emotion and sociocognitive processing in brief treatments. It will help increase the effectiveness of initial treatment phase for BPD and help diminish the societal burden of disease related with BPD. This study is funded by the Swiss National Science Foundation (SNSF).

Detailed Description

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Conditions

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Borderline Personality Disorder

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Good Psychiatric Management-Brief

Group Type EXPERIMENTAL

Good Psychiatric Management - Brief

Intervention Type BEHAVIORAL

specific interventions as defined by Gunderson and Links (2014)

Treatment as Usual-Brief

Group Type PLACEBO_COMPARATOR

treatment as usual

Intervention Type BEHAVIORAL

non-specific intervention

Interventions

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Good Psychiatric Management - Brief

specific interventions as defined by Gunderson and Links (2014)

Intervention Type BEHAVIORAL

treatment as usual

non-specific intervention

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Borderline Personality Disorder
* age between 18 and 35

Exclusion Criteria

* non-mastery in French
* neurological disorders
* schizophrenia (according to DSM-5)
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Lausanne Hospitals

OTHER

Sponsor Role lead

Responsible Party

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Ueli Kramer

PD Dr. phil. Head of Research

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Psychiatry-CHUV, University of Lausanne

Lausanne, Canton of Vaud, Switzerland

Site Status RECRUITING

Countries

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Switzerland

Facility Contacts

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Ueli Kramer, PhD PD

Role: primary

+41 21 314 00 50

References

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Kramer U, Kolly S, Maillard P, Pascual-Leone A, Samson AC, Schmitt R, Bernini A, Allenbach G, Charbon P, de Roten Y, Conus P, Despland JN, Draganski B. Change in Emotional and Theory of Mind Processing in Borderline Personality Disorder: A Pilot Study. J Nerv Ment Dis. 2018 Dec;206(12):935-943. doi: 10.1097/NMD.0000000000000905.

Reference Type RESULT
PMID: 30507735 (View on PubMed)

Kramer U, Grandjean L, Machinea JB, Beuchat H, Ranjbar S, de Roten Y, Despland JN, Conus P, Kolly S. Emotional processing as mechanism of change in brief good psychiatric management for borderline personality disorder: results of a randomized controlled trial. BMC Psychiatry. 2024 Dec 18;24(1):921. doi: 10.1186/s12888-024-06370-2.

Reference Type DERIVED
PMID: 39696018 (View on PubMed)

Kramer U, Grandjean L, Beuchat H, Kolly S, Conus P, de Roten Y, Draganski B, Despland JN. Mechanisms of change in brief treatments for borderline personality disorder: a protocol of a randomized controlled trial. Trials. 2020 Apr 16;21(1):335. doi: 10.1186/s13063-020-4229-z.

Reference Type DERIVED
PMID: 32299512 (View on PubMed)

Other Identifiers

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2017-02167

Identifier Type: -

Identifier Source: org_study_id

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