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Outcomes of Mentalization-Based Treatment for Borderline Personality Disorder

NCT ID: NCT03295838

Last Updated: 2017-09-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

75 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-02-01

Study Completion Date

2014-05-03

Brief Summary

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The effects of a psychological treatment, Mentalization-Based Treatment, was studied using a research protocol with patients with mood swings and impulsive behavior (borderline personality disorder).

Detailed Description

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Background: Mentalization-based treatment (MBT) in borderline personality disorder (BPD) has a growing evidence base, but there is a lack of effectiveness and moderator studies. The present study examined the effectiveness of MBT in a naturalistic setting and explored psychiatric and psychological moderators of outcome. Method: Borderline and general psychiatric symptoms, suicidality, self-harm, alexithymia and self-image were measured in a group of BPD patients (n=75) receiving MBT; assessments were made at baseline, and subsequently after 6, 12 and 18 months (when treatment ended). Borderline symptoms were the primary outcome variable.

Conditions

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Borderline Personality Disorder

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Patients were selected using a research protocol with defined criteria, all patients that were intended to treat in the Mentalization-based Treatment program were followed over 18 months and assessed for primary and secondary outcomes.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mentalization-based Treatment

MBT was conducted according to the treatment manual developed by Bateman \& Fonagy. Patients were offered individual sessions with a psychotherapist and group sessions with 6-8 participants and 1-2 group therapists for 18 months. An introductory psycho-educational component (9-12 sessions) was also offered focusing on explicit mentalising skills (i.e. understanding one's own or others' intentions). Group and individual MBT focused on implicit mentalising towards self and others.

Group Type EXPERIMENTAL

Mentalization-based treatment

Intervention Type BEHAVIORAL

See Arm description

Interventions

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Mentalization-based treatment

See Arm description

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* To be included, BPD diagnosis was confirmed by SCID-II interview and the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) interview, together with a consensus discussion between MBT therapists using DSM-IV and ICD-10 criteria. All patients referred between 2007-02-01 and 2012-05-30 were eligible for inclusion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Karolinska Institutet

OTHER

Sponsor Role lead

Responsible Party

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Viktor Kaldo

Med PhD, clinical psychologist, associate professor, research team leader

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Viktor Kaldo, PhD

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

References

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Lof J, Clinton D, Kaldo V, Ryden G. Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study. BMC Psychiatry. 2018 Jun 11;18(1):185. doi: 10.1186/s12888-018-1699-6.

Reference Type DERIVED
PMID: 29890960 (View on PubMed)

Other Identifiers

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DNR 2011/1909-31/3

Identifier Type: -

Identifier Source: org_study_id