The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health

NCT ID: NCT03716791

Last Updated: 2021-10-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

43 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-02-19

Study Completion Date

2021-08-11

Brief Summary

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Obesity- related diseases are linked to elevated levels of inflammation, oxidative stress, and metabolic dysfunction. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and type 2 diabetes following MSM treatment. However, the effect of MSM on obesity-related risk factors for disease in humans has not been investigated. Therefore, the purpose of this investigation will be to determine whether MSM supplementation improves metabolic health, and markers of inflammation and oxidative status.

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Double-blind placebo controlled randomized controlled trial
Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo Control Group

pill capsules containing white rice flour

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DIETARY_SUPPLEMENT

white rice flour

Methylsulfonylmethane Group

pill capsules containing MSM

Group Type ACTIVE_COMPARATOR

methylsulfonylmethane

Intervention Type DIETARY_SUPPLEMENT

3g per day

Interventions

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methylsulfonylmethane

3g per day

Intervention Type DIETARY_SUPPLEMENT

placebo

white rice flour

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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MSM

Eligibility Criteria

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Inclusion Criteria

* overweight or obese adults without any diagnosed disease or current medications other than birth control. Participants must agree to maintain diet and physical activity levels throughout study.

Exclusion Criteria

* normal weight adults, or overweight/obese adults that do not meet the criteria for metabolically unhealthy obesity. Individuals currently on medications, or with diagnosed disease. Pregnant or nursing women, or women planning to become pregnant within the study timeframe. Lack of access to reliable transportation to study site, lack of internet access, or non-english speaking.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Lindsey Miller

OTHER

Sponsor Role lead

Responsible Party

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Lindsey Miller

Assistant Professor

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Lindsey E Miller, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Washington State University

Locations

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Washington State University

Spokane, Washington, United States

Site Status

Countries

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United States

Other Identifiers

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16970-001

Identifier Type: -

Identifier Source: org_study_id

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