Inulin and Acetate Production and Human Substrate Metabolism
NCT ID: NCT03711383
Last Updated: 2020-01-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2018-02-20
2018-11-15
Brief Summary
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To investigate the effects of an acute administration of inulin/beta glucan in combination with resistant starch on fecal and plasma acetate, as well as on fasting and postprandial substrate and energy metabolism in lean normoglycemic men and obese, prediabetic men.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Placebo
isocaloric maltodextrin the day before CIDs
Placebo
isocaloric maltodextrin before test day
Inulin
12 g of inulin + isocaloric maltodextrin the day before CID
Inulin
12g per inulin in combination with maltodextrin per day the day before the CID
Inulin and Resistant Starch
12 g inulin + 7.5 g resistant starch the day before CID
Inulin and Resistant Starch
12g per inulin in combination 7.5 g resistant starch per day the day before the CID Resistant starch 7.5 g
Interventions
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Inulin and Resistant Starch
12g per inulin in combination 7.5 g resistant starch per day the day before the CID Resistant starch 7.5 g
Inulin
12g per inulin in combination with maltodextrin per day the day before the CID
Placebo
isocaloric maltodextrin before test day
Eligibility Criteria
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Inclusion Criteria
* normoglycemic
* aged 30 - 65 years
OR
* overweight/obese (BMI ≥ 25kg/m2 and ≤ 34.9kg/m2)
* pre-diabetes
* aged between 30 - 65 years.
Exclusion Criteria
* gastroenterological diseases or major abdominal surgery (allowed i.e.: - appendectomy, cholecystectomy)
* lactose intolerance and other digestive disorders
* cardiovascular disease, cancer, liver or kidney malfunction (determined -based on ALAT and creatinine levels, respectively)
* disease with a life expectancy shorter than 5 years
* Use of antibiotics 3 months prior inclusion
* Use of probiotics or prebiotics
30 Years
65 Years
MALE
Yes
Sponsors
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Maastricht University Medical Center
OTHER
Responsible Party
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Locations
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Maastricht University Medical Centre
Maastricht, , Netherlands
Countries
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References
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Canfora EE, Hermes GDA, Muller M, Bastings J, Vaughan EE, van Den Berg MA, Holst JJ, Venema K, Zoetendal EG, Blaak EE. Fiber mixture-specific effect on distal colonic fermentation and metabolic health in lean but not in prediabetic men. Gut Microbes. 2022 Jan-Dec;14(1):2009297. doi: 10.1080/19490976.2021.2009297.
Other Identifiers
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NL63754.068.17
Identifier Type: -
Identifier Source: org_study_id
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