Extracorporeal Carbon Dioxide Removal in Severe Chronic Obstructive Pulmonary Disease Exacerbation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-01-31

Study Completion Date

2020-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The conventional treatment for Severe acute exacerbation of Chronic obstructive pulmonary disease including noninvasive respiratory support, invasive respiratory support, etc, but there are many kinds of limitations and complications. Extracorporeal Carbon Dioxide Removal is a life support technology, which can effectively remove CO2. Recently some clinical studies have showed that ECCO2R can effectively improve the AECOPD patient's respiratory failure, avoid intubation and removal of endotracheal intubation. We performed a study to evaluate the clinical effectiveness of ECCO2R in the treatment of AECOPD patients.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

ECCO2R in the Treatment of Acute Exacerbation of COPD With Severe Hypercapnia

NCT04842344

Lung Diseases, Obstructive

UNKNOWN NA

Extracorporeal CO2 Removal in COPD Exacerbation

NCT01422681

COPD Exacerbation

COMPLETED PHASE2

Extracorporeal CO2 Removal in Acute Exacerbation of COPD Not Responding to Non-Invasive Ventilation

NCT04882410

COPD Exacerbation Acute

COMPLETED

ecco2R to facilitatE earLy libEration From mechanicAl Ventilation inpatientS With Copd Acute Exacerbation

NCT04147104

Acute Exacerbation of COPD

UNKNOWN NA

Physiological Study of Minimally Invasive ECCO2R in Exacerbations of COPD Requiring Invasive Mechanical Ventilation

NCT02586948

Chronic Obstructive Pulmonary Disease

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

With the development of technology, ECCO2R is not difficult to implement in intensive care unit. Many recently clinical studies have showed that ECCO2R can effectively remove CO2, reduce patient breathing work, improve the patient respiratory failure, and avoid endotracheal intubation. But there are also treated failure and high incidence of complications such as bleeding in the AECOPD patients with ECCO2R treatment, and the treatment related to airway management are less mentioned. Therefore, we set a more strict inclusion criteria in AECOPD patients and evaluate the clinical effectiveness and associated risk of ECCO2R in the treatment of AECOPD.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

COPD Exacerbation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Extracorporeal Carbon Dioxide Removal

Place a double lumen catheter in jugular vein, drainage the venous blood in vitro tube, after blood-gas exchange and remove CO2, then return back to the Superior vena cava

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* NPPV treatment failure:

1. deterioration or no improvement after treatment with NPPV, pH \< 7.25, PaCO2 \> 70mmHg
2. Obvious respiratory distress, RR \> 30 times/min
3. Breathing extreme fatigue

Exclusion Criteria

* Older than 75 years
* endotracheal intubation or tracheostomy
* obviously a lot of pus yellow phlegm, expectorate difficult
* Chest CT: obviously a wide range of consolidation
* BMI \< 20 kg/m2,
* Dysfunction of other organ of extrapulmonary
* serious hemodynamic instability
* severe hypoxemia, PaO2 / FiO2 \< 100mmHg
* home noninvasive positive pressure ventilation for a long time
* lung fungal infection
* contraindication of anticoagulation
* Platelet \< 80000 per cubic millimeter
* Serum creatinine \> 200 umol/L
* cardiac arrest
* Hospice care
* Refused to take part in the study

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No