Indication to Transplant Patients With High Risk B Cells Lymphoma in Metabolic Complete Remission?

NCT ID: NCT03681938

Last Updated: 2018-09-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

183 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-07-03

Study Completion Date

2019-07-28

Brief Summary

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The autograft of patients with prognostically unfavourable B-cells lymphoma cells in first remission remains controversial, in particular since the association of Rituximab with chemotherapy. Even though many randomized and non-randomized studies have been conducted, their is still no standard procedure . Recently, the use of early TEP (positron emission topography) answer, after 2 in 3 cures of chemotherapy allowed to select the poor-responder patients who remain candidate to autograft in front-line. Nevertheless, in good-responder patients, the benefits of an intensification therapy ins term of long-lasting disease control remains discussion.

This institutional retrospective study aims at comparing the outcome of early metabolic responder patients who received an intensification treatment to those who received a standard chemotherapy.

Detailed Description

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Conditions

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Lymphoma, B-Cell

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Intensification treatment: Autograft

Autograft

Intervention Type PROCEDURE

Autograft

Standard chemotherapy (without autograft)

No interventions assigned to this group

Interventions

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Autograft

Autograft

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients with High Risk Big B Cells Lymphoma
* Age \> 18 years

Exclusion Criteria

* Not applicable
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institut Paoli-Calmettes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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BOUABDALLAH Réda, MD

Role: PRINCIPAL_INVESTIGATOR

Institut Paoli-Calmettes

Locations

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Institut Paoli-Calmettes

Marseille, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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ALERT-IPC 2017-015

Identifier Type: -

Identifier Source: org_study_id

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