Rituximab and Combination Chemotherapy in Treating Older Patients With Previously Untreated B-Cell Lymphoma

NCT ID: NCT00290667

Last Updated: 2021-05-18

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 586 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-02-29
• Study Completion Date: 2015-11-30

Brief Summary

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some find cancer cells and kill them or carry cancer-killing substances to them. Others interfere with the ability of cancer cells to grow and spread. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving rituximab together with combination chemotherapy may kill more cancer cells.

PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy works in treating older patients with previously untreated B-cell lymphoma.

Detailed Description

OBJECTIVES:

Primary

• Determine a pharmacokinetic profile for pharmacokinetics-based or rituximab within a CHOP-14 regimen comprising cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone in elderly patients with previously untreated aggressive B-cell lymphoma.
• To determine whether increased single-doses of rituximab for males can compensate their lower serum levels.
• Evaluate the safety and toxicity profile of this regimen in male patients.

Secondary

• Determine the rate of complete responses, primary progressions under therapy, event-free survival, progression-free survival, and overall survival in patients treated with this regimen.
• Determine the rate of primary progression in patients treated with this regimen.

OUTLINE: This is a multicenter study. All patients undergo the following treatment.

• Prephase treatment: Patients receive vincristine subcutaneously on day -6 and oral prednisone on days -6 to 0.
• Immunochemotherapy and radiotherapy: Patients receive CHOP chemotherapy comprising cyclophosphamide IV over 15 minutes, doxorubicin hydrochloride IV, and vincristine IV on day 1 and oral prednisone once daily on days 1-5. Patients also receive pegfilgrastim subcutaneously on days 4, 18, 32, 46, 60, and 74. Treatment with CHOP chemotherapy repeats every 14 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. Patients who show no response after course 4 of CHOP chemotherapy proceed to salvage chemotherapy off study.

Patients are evaluated 2-4 weeks after completion of CHOP. Patients with initial bulky disease (i.e., diameter ≥ 7.5 cm) or extranodal involvement AND achieving complete remission (CR), unconfirmed CR (CRu), or partial remission undergo radiotherapy 5 days a week for 4 weeks. Patients who do not achieve CR or CRu 2 months after completion of radiotherapy proceed to salvage chemotherapy off study.

Patients are then stratified according to center, International Prognostic Index (1-2 vs 3-5), disease involvement (bulky vs extranodal vs bulky and/or extranodal), age (61-70 years old vs 71-80 years old), and gender. Patients are randomized to 1 of 2 treatment arms.

• Arm I (2-weekly rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days 0, 14, 28, 42, 56, 70, 84, and 98. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.
• Arm II (pharmacokinetic-based dose-dense rituximab): Patients receive rituximab IV 375 mg/m^2 (females) and 500 mg/m^2 (males) over 4 hours on days -1, 0, 3, 7, 14, 21, 28, and 42. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.

Some patients undergo blood sample collection periodically during and after treatment for pharmacokinetic studies.

After completion of study treatment, patients are followed every 3 months for 2 years, every 6 months for 3 years, and then once a year therafter.

Conditions

Lymphoma

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Interventional: CHOP-14 + 8 x 2-weekly rituximab

Arm I (2-weekly rituximab): Patients receive rituximab IV 375 mg/m\^2 (females) and 500 mg/m\^2 (males) over 4 hours on days 0, 14, 28, 42, 56, 70, 84, and 98. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.

Group Type: ACTIVE_COMPARATOR

pegfilgrastim

Intervention Type: BIOLOGICAL

rituximab

Intervention Type: BIOLOGICAL

cyclophosphamide

Intervention Type: DRUG

doxorubicin hydrochloride

Intervention Type: DRUG

prednisone

Intervention Type: DRUG

vincristine sulfate

Intervention Type: DRUG

pharmacological study

Intervention Type: OTHER

radiation therapy

Intervention Type: RADIATION

Interventional: CHOP-14 + 8 x dose-dense rituximab

Arm II (pharmacokinetic-based dose-dense rituximab): Patients receive rituximab IV 375 mg/m\^2 (females) and 500 mg/m\^2 (males) over 4 hours on days -1, 0, 3, 7, 14, 21, 28, and 42. Patients also receive pegfilgrastim subcutaneously on day 4 of each course.

Group Type: ACTIVE_COMPARATOR

pegfilgrastim

Intervention Type: BIOLOGICAL

rituximab

Intervention Type: BIOLOGICAL

cyclophosphamide

Intervention Type: DRUG

doxorubicin hydrochloride

Intervention Type: DRUG

prednisone

Intervention Type: DRUG

vincristine sulfate

Intervention Type: DRUG

pharmacological study

Intervention Type: OTHER

radiation therapy

Intervention Type: RADIATION

Interventions

pegfilgrastim

Intervention Type: BIOLOGICAL

rituximab

Intervention Type: BIOLOGICAL

cyclophosphamide

Intervention Type: DRUG

doxorubicin hydrochloride

Intervention Type: DRUG

prednisone

Intervention Type: DRUG

vincristine sulfate

Intervention Type: DRUG

pharmacological study

Intervention Type: OTHER

radiation therapy

Intervention Type: RADIATION

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histological diagnosis of aggressive B-cell lymphoma

• Previously untreated disease
• Stage I-IV disease
• CD20-positive disease
• Any International Prognostic Index (IPI) score
• No secondary lymphoma after prior chemotherapy or radiotherapy
• No primary CNS lymphoma
• No primary gastrointestinal (MALT) lymphoma

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2
• Life expectancy ≥ 3 months
• AST and ALT ≤ 3 times normal unless related to lymphoma
• Bilirubin ≤ 2 mg/dL unless related to lymphoma
• Creatinine ≤ 2 times normal unless related to lymphoma
• Fertile patients must use effective contraception
• No known allergic reactions against foreign proteins
• No active infections requiring systemically administered antibiotics or antiviral medications
• No noncompensated heart failure
• No dilatative cardiomyopathy
• No coronary heart disease with ST-segment depression in ECG
• No myocardial infarction during the past 6 months
• No chronic lung disease with hypoxemia
• No severe noncompensated hypertension
• No severe noncompensated diabetes mellitus
• No clinical signs of cerebral dysfunction
• No severe psychiatric disease
• No known HIV infection
• No active chronic hepatitis B or C infection
• No other concurrent diseases that exclude the administration of therapy as outlined by the study protocol

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics
• More than 12 weeks since prior clinical trial participation
• No prior participation in this study
• No prior therapy, including murine antibody, for this cancer
• No prior organ transplantation
• No concurrent response-adapted radiotherapy ("iceberg radiotherapy")
• No other concurrent anticancer chemotherapy or other study medication

• Minimum Eligible Age: 61 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

German High-Grade Non-Hodgkin's Lymphoma Study Group

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Michael G.M. Pfreundschuh, MD

Role: STUDY_CHAIR

Universitaetsklinikum des Saarlandes

Norbert Schmitz, MD, PhD

Role: STUDY_CHAIR

Asklepios Klinik St. Georg

Locations

University Hospital Brno

Brno, , Czechia

Charles University Hospital

Prague, , Czechia

Hopital Debrousse

Lyon, , France

Haematologisch Onkologische Praxis

Aachen, , Germany

Ostalb-Klinikum Aalen

Aalen, , Germany

Klinikum St. Marien

Amberg, , Germany

Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie

Ansbach, , Germany

Specialist Practice for Oncology

Aschaffenburg, , Germany

II. Medizinische Klinik

Aschaffenburg, , Germany

Haematologische Praxis

Augsburg, , Germany

Hamatologische/Onkologische Gemeinschaftspraxis - Augsburg

Augsburg, , Germany

Klinikum Augsburg

Augsburg, , Germany

Kreiskrankenhaus Aurich

Aurich, , Germany

Regional Hospital Bad Hersfeld

Bad Hersfeld, , Germany

HELIOS Klinikum Bad Saarow

Bad Saarow, , Germany

Internistische Praxis - Bad Salzuflen

Bad Salzuflen, , Germany

Kreiskrankenhaus Bad Saeckingen

Bad Säckingen, , Germany

Onkologische Schwerpunktpraxis und Tagesklinik Dres

Bad Soden, , Germany

Ermstalklinik Bad Urach

Bad Urach, , Germany

Klinikum am Bamberg

Bamberg, , Germany

Krankenhaus Hohe Warte Mediziniche Klinik

Bayreuth, , Germany

Klinikum Bayreuth

Bayreuth, , Germany

Praxis Dr. med. Stefan Korsten

Bergisch Gladbach, , Germany

Onkologisches Versorgungszentrum Friedrichshain

Berlin, , Germany

DRK Kliniken Berlin - Koepenick

Berlin, , Germany

Internistische Gemeinschaftspraxis - Berlin

Berlin, , Germany

Haematologisch-Onkologische Schwerpunktpraxis

Berlin, , Germany

Evang. Waldkrankenhaus Spandau

Berlin, , Germany

Internistische Gemeinschaftspraxis - Berlin

Berlin, , Germany

Charite - Campus Charite Mitte

Berlin, , Germany

Onkolog - Haematolog Schwerpunktpraxis

Berlin, , Germany

Charite - Universitaetsmedizin Berlin - Campus Benjamin Franklin

Berlin, , Germany

Vivantes Klinikum Neukoelln

Berlin, , Germany

Robert Roessle Comprehensive Cancer Center - Charite Campus Buch

Berlin, , Germany

Hospital Complex Bernburg

Bernburg, , Germany

Franziskus Hospital

Bielefeld, , Germany

Krankenhaus Bietigheim

Bietigheim, , Germany

Saint Agnes Hospital

Bocholt, , Germany

Augusta-Kranken-Anstalt gGmbH

Bochum, , Germany

St. Josef-Hospital - Bochum

Bochum, , Germany

Knappschaftskrankenhaus Bochum-Langendreer

Bochum, , Germany

Johanniter-Krankenhaus Bonn

Bonn, , Germany

Universitaetsklinikum Bonn

Bonn, , Germany

Medizinische Poliklinik

Bonn, , Germany

Praxis fuer Haematologie und Internistische Onkologie - Borken

Borken, , Germany

Knappschaftskrankenhaus Bottrop

Bottrop, , Germany

Hamatologische Sprechstunde

Brandenburg, , Germany

Staedtisches Klinikum Braunschweig

Braunschweig, , Germany

Praxis Dres. F.& G. Doering

Bremen, , Germany

Klinikum Bremen-Mitte

Bremen, , Germany

DIAKO Ev. Diakonie Krankenhaus gGmbH

Bremen, , Germany

St. Joseph Hospital

Bremerhaven, , Germany

Zentralkrankenhaus

Bremerhaven, , Germany

Praxis fuer Haematologie und Onkologie - Burgwedel

Burgwedel, , Germany

Medizinische Klinik am Lukas - Krankenhaus

Bünde, , Germany

General Hospital

Celle, , Germany

Onkologische Schwerpunktpraxis Celle

Celle, , Germany

Hospital Kuchwald Chemnitz

Chemnitz, , Germany

Klinikum Coburg

Coburg, , Germany

Internistische Praxis - Coesfeld

Coesfeld, , Germany

Praxis Internistischer Onkologie und Haematologie - Koeln

Cologne, , Germany

Kliniken der Stadt Koeln gGmbH - Krankenhaus Holweide

Cologne, , Germany

Praxis fuer Onkologie - Kalk

Cologne, , Germany

Praxis Fuer Haematologie Internistische Onkologie

Cologne, , Germany

Medizinische Universitaetsklinik I at the University of Cologne

Cologne, , Germany

Lung Clinic Cologne-Merheim

Cologne-Merheim, , Germany

Carl - Thiem - Klinkum Cottbus

Cottbus, , Germany

Praxis Dr. Rheinhold Siegmund - Dr. Matthias Penke

Damme, , Germany

Klinikum Darmstadt

Darmstadt, , Germany

Staedtisches Klinikum Dessau

Dessau, , Germany

Internistische Praxis

Detmold, , Germany

Saint Johannes Hospital Dortmund

Dortmund, , Germany

Klinikum Dortmund

Dortmund, , Germany

Universitatsklinikum Carl Gustav Carus

Dresden, , Germany

Johanniter-Krankenhaus Rheinhausen GmbH

Duisburg, , Germany

St. Johannes Hospital - Medical Klinik II

Duisburg, , Germany

Franz Hospital Dulmen

Dülmen, , Germany

Florence-Nightingale-Krankenhause, Deaconess Kaiserswerth

Düsseldorf, , Germany

Universitaetsklinikum Duesseldorf

Düsseldorf, , Germany

Klinikum Barnim GmbH, Werner Forssmann Krankenhaus

Eberswalde, , Germany

Virngrund-Klinik Ellwangen

Ellwangen, , Germany

Hans - Susemihl - Krankenhaus

Emden, , Germany

Helios Klinikum Erfurt

Erfurt, , Germany

Medizinische Klinik III - Universitaetsklinikum Erlangen

Erlangen, , Germany

St. Antonius Hospital

Eschweiler, , Germany

Universitaetsklinikum Essen

Essen, , Germany

Evangelisches Krankenhaus Essen Werden

Essen, , Germany

Staedtische Kliniken Esslingen

Esslingen am Neckar, , Germany

Schwerpunktpraxis fuer Haematologie und Onkologie - Flensburg

Flensburg, , Germany

Gemeinschaftspraxis fuer Internistische - Frankenthal

Frankenthal, , Germany

Onkologie Bethanien

Frankfurt, , Germany

Krankenhaus Nordwest

Frankfurt, , Germany

Klinikum der J.W. Goethe Universitaet

Frankfurt, , Germany

Klinikum Frankfurt (Oder) GmbH

Frankfurt (Oder), , Germany

St. Marienkrankenhaus - Frankfurt am Main

Frankfurt am Main, , Germany

Praxis Internistischer Onkologie und Haematologie - Frechen

Frechen, , Germany

Gemeinschaftspraxis - Freiburg

Freiburg im Breisgau, , Germany

Evang. Deaconess Hospital Freiburg

Freiburg im Breisgau, , Germany

Praxis fur Interdisziplinaere Onkologie

Freiburg im Breisgau, , Germany

Universitaetsklinikum Freiburg

Freiburg im Breisgau, , Germany

Municipal Hospital Complex

Fulda, , Germany

Klinikum Garmisch - Partenkirchen GmbH

Garmisch-Partenkirchen, , Germany

Robert - Koch Hospital

Gehrden, , Germany

Saint Josef Hospital

Gelsenkirchen, , Germany

Internistische Praxisgemeinschaft

Germering, , Germany

Centre for Internal Medicine Giessen

Giessen, , Germany

Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie

Giessen, , Germany

Wilhelm-Anton-Hospital gGmbH, Goch

Goch, , Germany

DR Herbert - Nieper Krankenhaus Goslar

Goslar, , Germany

Staedtisches Klinikum Görlitz GmbH

Görlitz, , Germany

Universitaetsklinikum Göttingen

Göttingen, , Germany

Klinik Fuer Innere Medizin, Hematology/Oncology, Ernst Moritz Armdt Universitaet

Greifswald, , Germany

Kreiskrankenhaus Gummersbach GMBH

Gummersbach, , Germany

Internistisch-Haematologische Gemeinschaftspraxis - Gustrow

Güstrow, , Germany

Staedtisches Klinikum Gütersloh

Gütersloh, , Germany

Allgemeines Krankenhaus Hagen

Hagen, , Germany

St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH

Hagen, , Germany

St. Salvator Krankenhaus

Halberstadt, , Germany

Internistische Gemeinschaftspraxis - Halle

Halle, , Germany

Universitaetsklinikum Halle

Halle, , Germany

Krankenhaus St. Elisabeth und St. Barbara

Halle, , Germany

Krankenhaus Martha-Maria Halle-Doelau gGmbH

Halle, , Germany

St. Sixtus Hospital

Haltern, , Germany

Praxis fuer Innere Medizin - Bergedorf

Hamburg, , Germany

Marienkrankenhaus

Hamburg, , Germany

Allgemeines Krankenhaus Altona

Hamburg, , Germany

Onkologische Schwerpunktpraxis Dr. med. Verpoort, PD Dr. med. Zeller and Dr. med. Wierecky

Hamburg, , Germany

Asklepios Klinik St. Georg

Hamburg, , Germany

University Medical Center Hamburg - Eppendorf

Hamburg, , Germany

Asklepios Klinik Nord Heidberg

Hamburg, , Germany

Haematologisch-Onkologische Praxis Altona

Hamburg, , Germany

St. Marien Hospital

Hamm, , Germany

Evangelische Krankenhaus Hamm

Hamm, , Germany

Klinikum Stadt Hanau

Hanau, , Germany

Schwerpunktpraxis Haematologie/Onkologie - Hannover

Hanover, , Germany

Krankenhaus Siloah - Medizinische Klinik II

Hanover, , Germany

Henriettenstiftung Frauenklinik

Hanover, , Germany

Medizinische Hochschule Hannover

Hanover, , Germany

Oncology Specialists Clinic

Harrislee, , Germany

Ruprecht - Karls - Universitaet Heidelberg

Heidelberg, , Germany

Thoraxklinik Heidelberg

Heidelberg, , Germany

Regional Hospital Heidenheim

Heidenheim, , Germany

Regional Hospital Am Plattenwald Bad Friedrichshall

Heilbronn, , Germany

Klinikum Herford

Herford, , Germany

Marienhospital at Ruhr University Bochum

Herne, , Germany

Privatklinik Dr. R. Schindlbeck GmbH & Co. KG

Herrsching am Ammersee, , Germany

Onkologische Schwerpunktpraxis

Hildesheim, , Germany

St. Bernward Krankenhaus

Hildesheim, , Germany

Staedtisches Krankenhaus Hildesheim

Hildesheim, , Germany

Evang. Hospital

Holzminden, , Germany

Haematologie und Internistische Onkologie Praxis

Homberg (Efze), , Germany

Universitaetsklinikum des Saarlandes

Homburg, , Germany

Hospital Complex Hoyerswerda

Hoyerswerda, , Germany

Clinic for Bone Marrow Transplantation and Hematology and Oncology

Idar-Oberstein, , Germany

Internistische Gemeinschaftspraxis - Jena

Jena, , Germany

Klinikum der Friedrich-Schiller Universitaet Jena

Jena, , Germany

Onkologische Gemeinschaftspraxis - Kaiserslautern

Kaiserslautern, , Germany

Westpfalz-Klinikum GmbH

Kaiserslautern, , Germany

Staedtisches Klinikum Karlsruhe gGmbH

Karlsruhe, , Germany

St. Vincentius - Kliniken

Karlsruhe, , Germany

Red Cross Hospital Kassel

Kassel, , Germany

Internistische Gemeinschaftspraxis - Kassel

Kassel, , Germany

Klinikum Kempten Oberallgaeu

Kempten, , Germany

Staedtisches Krankenhaus Kiel

Kiel, , Germany

Praxis fuer Haematologie und Onkologie

Koblenz, , Germany

Stiftungsklinikum Mittelrhein - Gesundheitszentrum Evangelisches Stift Sankt Martin Koblenz gGmbH

Koblenz, , Germany

Leonardis Clinic

Kornwestheim, , Germany

Haematologische / Onkologische Schwerpunktpraxis

Krefeld, , Germany

Klinikum Krefeld GmbH

Krefeld, , Germany

Internistische Onkologische Praxis - Kronach

Kronach, , Germany

Frankenwald Klinik

Kronach, , Germany

Internistische Praxis - Landshut

Landshut, , Germany

Klinikum Landshut

Landshut, , Germany

Caritas - Krakenhaus Lebach

Lebach, , Germany

Onkologische Schwerpunktpraxis - Leer

Leer, , Germany

Praxis fuer Onkologie am Diakonissenhaus

Leipzig, , Germany

Forschungsgesellschaft mbH

Leipzig, , Germany

Gemeinschaftspraxis fuer Dres. Aldaoud und Schwarzer

Leipzig, , Germany

University Leipzig Clinic of Internal Medicine

Leipzig, , Germany

Klinikum "St. Georg" Leipzig

Leipzig, , Germany

Klinikum Lippe - Lemgo

Lemgo, , Germany

St. Vincenz Hospital Limburg

Limburg, , Germany

St. Bonifatius Hospital Lingen

Lingen, , Germany

Dreifaltigkeits Hospital

Lippstadt, , Germany

Kreiskrankenhaus Loerrach

Loerrach, , Germany

Onkologische Schwerpunktpraxis

Loerrach, , Germany

Klinikum Ludwigsburg

Ludwigsburg, , Germany

St. Marien Hospital Ludwighafen

Ludwigshafen, , Germany

Klinikum der Stadt Ludwigshafen am Rhein

Ludwigshafen am Rhein, , Germany

Schwerpunktpraxis fuer Haematologie und Onkologie - Luebeck

Lübeck, , Germany

Universitaetsklinikum Schleswig-Holstein - Campus Luebeck

Lübeck, , Germany

Sana Kliniken Luebeck

Lübeck, , Germany

Kreiskrankenhaus Luedenscheid

Lüdenscheid, , Germany

Universitatsklinikum der MA

Magdeburg, , Germany

Staedtisches Klinikum Magdeburg - Altstadt

Magdeburg, , Germany

Internistische Gemeinschaftspraxis - Magdeburg

Magdeburg, , Germany

St. Vincenz und Elisabeth Hospital

Mainz, , Germany

Johannes Gutenberg University

Mainz, , Germany

Gemeinschaftspraxis

Mannheim, , Germany

III Medizinische Klinik Mannheim

Mannheim, , Germany

Schwerpunktpraxis Internist Onkologie - Marburg

Marburg, , Germany

Universitaetsklinikum Giessen und Marburg GmbH - Marburg

Marburg, , Germany

Regional Hospital Mayen

Mayen, , Germany

Gemeinschaftspraxis Dres. med. Ellbrueck/Goeller/Kraenzle/Niedermeier/Jocham

Memmingen, , Germany

Krankenhaus Ludmillenstift

Meppen, , Germany

Gemeinschaftspraxis - Minden

Minden, , Germany

Klinikum Minden

Minden, , Germany

Ev. Hospital Bethesda

Mönchengladbach, , Germany

Krankenhaus Maria Hilf GmbH

Mönchengladbach, , Germany

Haematologische Praxis - Moenchengladbach

Mönchengladbach, , Germany

Universitaets - Kinderpoliklinik

Munich, , Germany

Krankenhaus Muenchen Schwabing

Munich, , Germany

Munich Oncologic Practice at Elisenhof

Munich, , Germany

Klinikum der Universitaet Muenchen - Grosshadern Campus

Munich, , Germany

Staedtisches Krankenhaus Muenchen - Harlaching

Munich, , Germany

Klinikum Rechts Der Isar - Technische Universitaet Muenchen

Munich, , Germany

Municipal Hospital Munich

Munich, , Germany

Klinikum Schwaebisch Gmuend Stauferklinik

Mutlangen, , Germany

Evangelisches Krankenhaus - Muelheim

Mülheim, , Germany

St. Marien Hospital - Muelheim an der Ruhr

Mülheim, , Germany

Kreiskrankenhaus Muenchberg

Münchberg, , Germany

Gemeinschaftspraxis - Muenster

Münster, , Germany

Haematologisch - Onkologische Gemeinschaftspraxis - Muenster

Münster, , Germany

Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster

Münster, , Germany

Staedtisches Krankenhaus Nettetal GmbH

Nettetal, , Germany

Klinikum Neubrandenburg

Neubrandenburg, , Germany

Onkologische Schwerwpunktpraxis Dr. Ladda

Neumarkt, , Germany

Regional Hospital Neumarkt

Neumarkt, , Germany

Onkologische Schwerpunktpraxis Dr. Schmidt

Neunkirchen, , Germany

Staedtisches Klinikum Neunkirchen gGmbH

Neunkirchen, , Germany

Internistische Praxis - Neuss

Neuss, , Germany

Lukaskrankenhaus Neuss

Neuss, , Germany

DRK Krankenhaus Neuwied

Neuwied, , Germany

Praxis fuer Haematologie und Interne Onkologie

Norderstedt, , Germany

Gemeinschaftspraxis fuer Onkologie - Nordhorn

Nordhorn, , Germany

Gemeinschaftspraxis fuer Haematologie - Northeim

Northeim, , Germany

Praxisklinik fuer Innere Medizin - Nuernberg

Nuremberg, , Germany

Klinikum Nuernberg - Klinikum Nord

Nuremberg, , Germany

Schlossbergkliniken Oberstaufen

Oberstaufen, , Germany

Internistische Gemeinschaftspraxis - Offenbach

Offenbach, , Germany

Klinikum Offenburg

Offenburg, , Germany

Pius Hospital - Oldenburg

Oldenburg, , Germany

Internistische Gemeinschaftspraxis - Oldenburg

Oldenburg, , Germany

Ev. Hospital Oldenburg

Oldenburg, , Germany

Klinikum Oldenburg

Oldenburg, , Germany

St. Martinus Hospital - Olpe

Olpe, , Germany

Marien Hospital

Osnabrück, , Germany

Klinikum Osnabrück GmbH

Osnabrück, , Germany

Paracelsus - Klinik Osnabrück

Osnabrück, , Germany

Bruederkrankenhaus St. Josef Paderborn

Paderborn, , Germany

Asklepios Klinik - Parchim

Parchim, , Germany

Staedtisches Krankenhaus

Pforzheim, , Germany

Krankenhaus Siloah - Pforzheim

Pforzheim, , Germany

Praxis fuer Innere Medizin am Krankenhaus Siloah - Pforzheim

Pforzheim, , Germany

Gemeinschaftspraxis - Pinneberg

Pinneberg, , Germany

Klinikum Ernst Von Bergmann

Potsdam, , Germany

Kreiskrankenhaus Radebeul

Radebeul, , Germany

Gemeinschaftspraxis - Ravensburg

Ravensburg, , Germany

Krankenhaus St. Elisabeth - Ravensburg

Ravensburg, , Germany

Elisabeth Krankenhaus

Recklinghausen, , Germany

Prosper-Hospital Recklinghausen

Recklinghausen, , Germany

Hematologische Onkologische Praxis

Regensburg, , Germany

Klinikum der Universitaet Regensburg

Regensburg, , Germany

Krankenhaus Barmherzige Brueder Regensburg

Regensburg, , Germany

Internistische Praxis Dres. Hempel und Hochdorfer

Rehling, , Germany

Klinikum Remscheid GmbH

Remscheid, , Germany

Jakobi Krankenhaus

Rheine, , Germany

Haematologische/Onkologische Schwerpunktpraxis - Rostock

Rostock, , Germany

Klinik und Poliklinik fuer Innere Medizin - Universitaet Rostock

Rostock, , Germany

Klinikum Suedstadt Rostock

Rostock, , Germany

Diakonie - Krankenhaus

Rotenburg (Wümme), , Germany

Internistische Schwerpunktpraxis

Rüsselsheim am Main, , Germany

Gemeinschaftspraxis - Saarbruecken

Saarbrücken, , Germany

Caritasklinik St. Theresia

Saarbrücken, , Germany

St. Elizabeth-Klinik Saarlouis

Saarlouis, , Germany

Martin - Luther Hospital

Schleswig, , Germany

Praxis fur Innere Medizin - Schmiedeberg

Schmiedeberg, , Germany

Deaconess Hospital

Schwäbisch Hall, , Germany

Gemeinschaftspraxis fuer Haematologie und Internist - Schweinfurt

Schweinfurt, , Germany

Leopoldina - Krankenhaus

Schweinfurt, , Germany

HELIOS Klinikum - Schwelm

Schwelm, , Germany

Klinikum Schwerin

Schwerin, , Germany

St. Marien - Krankenhaus Siegen GMBH

Siegen, , Germany

Evang. Jung-Stilling Hospital

Siegen, , Germany

St. Lukas - Clinic Solingen

Solingen, , Germany

Krankenhaus Maria-Hilf - Stadtlohn

Stadtlohn, , Germany

Onkologische Schwerpunktpraxis - Straubing

Straubing, , Germany

Hospital Bad Cannstatt

Stuttgart, , Germany

Haematologische Praxis

Stuttgart, , Germany

Klinik fuer Onkologie - Katharinenhospital Stuttgart

Stuttgart, , Germany

Diakonie Klinikum Stuttgart

Stuttgart, , Germany

Gastroenterologische und Haematologisch-Onkologische Praxis E. M. Dr. Hoering von Ehr Respondek

Stuttgart, , Germany

Klinikum Stuttgart - Buergerhospital

Stuttgart, , Germany

Robert-Bosch-Krankenhaus

Stuttgart, , Germany

St. Elisabeth Hospital Thuine

Thuine, , Germany

Regional Hospital Traunstein

Traunstein, , Germany

Onkologische Gemeinschaftspraxis - Trier

Trier, , Germany

Krankenanstalt Mutterhaus der Borromaerinnen

Trier, , Germany

Krankenhaus Der Barmherzigen Brueder

Trier, , Germany

Praxis Fuer Internistische Haematologie / Onkologie

Troisdorf, , Germany

Hospital Tutzing

Tutzing, , Germany

Universitaetsklinikum Tuebingen

Tübingen, , Germany

Praxis fuer Haematologie und Onkologie

Twistringen, , Germany

Comprehensive Cancer Center Ulm at Universitaetsklinikum Ulm

Ulm, , Germany

Ev. Hospital Unna

Unna, , Germany

St. Marienhospital - Vechta

Vechta, , Germany

Onkologische Schwerpunktpraxis - Villingen

Villingen, , Germany

Municipal Hospital Complex

Villingen-Schwenningen, , Germany

Regional Hospital Waldbrol

Waldbröl, , Germany

Haematologische Praxis

Weiden, , Germany

Gemeinschaftspraxis feur Haemotologie und Onkologie - Weilheim

Weilheim, , Germany

Sophien - und Hufeland - Klinikum Weimar gGmbH

Weimar, , Germany

Onkologische Schwerpunktpraxis

Wendlingen, , Germany

Harz-Klinikum Wernigerode-Blankenburg GmbH

Wernigerode, , Germany

Asklepios Nordseeklinik Westerland GmbH

Westerland, , Germany

Ammerland-Klinik GmbH

Westerstede, , Germany

Hospital Wetzler

Wetzlar, , Germany

Deutsche Klinik fuer Diagnostik

Wiesbaden, , Germany

Dr. Horst-Schmidt-Kliniken

Wiesbaden, , Germany

Ev. Hospital Witten-Herdecke

Witten, , Germany

Evangelisches Krankenhaus - Lutherstadt Wittenberg

Wittenberg, , Germany

Klinikum der Stadt Wolfsburg

Wolfsburg, , Germany

Burkhard and Reimann Gemeinschaftspraxis

Worms, , Germany

Helios Kliniken Wuppertal University Hospital

Wuppertal, , Germany

Kliniken St. Antonius

Wuppertal, , Germany

Medizinische Poliklinik, Universitaet Wuerzburg

Würzburg, , Germany

Heinrich-Braun-Krankenhaus Zwickau

Zwickau, , Germany

Azienda Ospedaliera di Padova

Padua, , Italy

Erasmus MC - Sophia Children's Hospital

Rotterdam, , Netherlands

Akademia Medyczna im. Piastow Slaskich

Wroclaw, , Poland

Goeteborg University

Gothenburg, , Sweden

Kantonsspital Aarau

Aarau, , Switzerland

Universitaets-Kinderspital beider Basel

Basel, , Switzerland

Ospedale "la Carita", Locarno

Locarno, , Switzerland

Kinderspital Luzern

Lucerne, , Switzerland

Ostschweizer Kinderspital

Sankt Gallen, , Switzerland

University Children's Hospital

Zurich, , Switzerland

Royal Manchester Children's Hospital

Manchester, England, United Kingdom

Countries

Czechia; France; Germany; Italy; Netherlands; Poland; Sweden; Switzerland; United Kingdom

Other Identifiers

DSHNHL-2004-1

Identifier Type: -

Identifier Source: secondary_id

EU-20536

Identifier Type: -

Identifier Source: secondary_id

DSHNHL-CHOP-R-ESC

Identifier Type: -

Identifier Source: secondary_id

EUDRACT-2005-00529-68

Identifier Type: -

Identifier Source: secondary_id

CDR0000454505

Identifier Type: -

Identifier Source: org_study_id