Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous

NCT ID: NCT03677908

Last Updated: 2018-09-19

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 28 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2016-07-01
• Study Completion Date: 2017-01-01

Brief Summary

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Detailed Description

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms.

Conditions

Premature Birth

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: RETROSPECTIVE

Study Groups

13 high

High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants

ElectroEncephaloGraphy

Intervention Type: OTHER

Density ElectroEncephaloGraphy analysis

15 low

Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants

ElectroEncephaloGraphy

Intervention Type: OTHER

Density ElectroEncephaloGraphy analysis

Interventions

ElectroEncephaloGraphy

Density ElectroEncephaloGraphy analysis

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy premature infants
• Gestational Ages of 26 and 32 wGA

Exclusion Criteria

• unhealthy premature infants

• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Fabrice Wallois, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

CHU AMIENS

Other Identifiers

PI2017_843_0048

Identifier Type: -

Identifier Source: org_study_id