TMS-induced Plasticity Improving Cognitive Control in OCD
NCT ID: NCT03667807
Last Updated: 2023-05-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
61 participants
INTERVENTIONAL
2019-05-08
2023-07-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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rTMS condition 1
Repetitive transcranial magnetic stimulation
Non invasive brain stimulation
rTMS condition 2
Repetitive transcranial magnetic stimulation
Non invasive brain stimulation
rTMS condition 3
Repetitive transcranial magnetic stimulation
Non invasive brain stimulation
Interventions
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Repetitive transcranial magnetic stimulation
Non invasive brain stimulation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age between 18 and 65
* Primary DSM-5 diagnosis of OCD
* Moderate to severe OCD symptoms (expressed as a minimum score of 16 on the Yale - Brown Obsessive Compulsive Scale (YBOCS)
* Unmedicated or stable dose of medication for at least 12 weeks prior to randomisation - with no plans to change dose during the study period
* At least 1 previous attempt at cognitive behavioural therapy (CBT) in lifetime
* At least 1 previous attempt with serotonergic medication or strong preference for non-pharmacological treatment
* Capacity to provide informed consent
Healthy controls (baseline measurements only):
* Age between 18 and 65
* Capacity to provide informed consent
Exclusion Criteria
* Schizophrenia, bipolar disorder, active suicidal ideation, use of antipsychotics within last 12 weeks
* previous experience with rTMS as treatment
Healthy controls:
* Current Diagnostic and Statistical Manual (DSM)-5 diagnosis
* Personal history of DSM-5 diagnosis
* use of psychotropic medications within last 12 months
* 1st degree family member with OCD
18 Years
65 Years
ALL
Yes
Sponsors
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Amsterdam UMC, location VUmc
OTHER
Responsible Party
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O.A. van den Heuvel
Professor of Neuropsychiatry
Locations
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Amsterdam UMC, location VU Medical Center
Amsterdam, North Holland, Netherlands
Countries
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References
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Fitzsimmons SMDD, Postma T, van Campen AD, Vriend C, Batelaan NM, van Oppen P, Hoogendoorn AW, van der Werf YD, van den Heuvel OA. TMS-induced plasticity improving cognitive control in OCD I: Clinical and neuroimaging outcomes from a randomised trial of rTMS for OCD. medRxiv [Preprint]. 2023 Nov 5:2023.11.04.23298100. doi: 10.1101/2023.11.04.23298100.
Other Identifiers
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91717306
Identifier Type: -
Identifier Source: org_study_id
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