Neurocircuitry of Obsessive-Compulsive Disorder: Modulation by Transcranial Magnetic Stimulation
NCT ID: NCT02704117
Last Updated: 2023-12-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
PHASE3
19 participants
INTERVENTIONAL
2015-06-30
2024-02-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Transcranial Magnetic Stimulation
Transcranial Magnetic Stimulation applied over the pre-supplementary motor area (pSMA), for ten sessions, Monday through Friday, over the course of two weeks.
Transcranial Magentic Stimulation
This is a form of mild brain stimulation delivered noninvasively. The device delivers pulses of magnetic energy through a coil placed on the scalp. The treatment takes 41 seconds, and takes place for ten sessions, Monday through Friday, over the course of two weeks
Interventions
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Transcranial Magentic Stimulation
This is a form of mild brain stimulation delivered noninvasively. The device delivers pulses of magnetic energy through a coil placed on the scalp. The treatment takes 41 seconds, and takes place for ten sessions, Monday through Friday, over the course of two weeks
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* 18-70 years of age
* Ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent
* No use of psychiatric medications or stable psychiatric medication use for a minimum of 6 week prior to study entry
* Ongoing psychotherapy allowed if already established for three months or more before study entry
Exclusion Criteria
* Present acute suicidality
* History of head injury, epilepsy, or other clinically significant neurological illness except tic disorders
* Active systemic medical (metabolic, endocrine, chronic inflammatory, vascular, autoimmune) disease
* Premorbid intelligence quotient (IQ) estimate \< 80
* Visual disturbance (\<20/40 Snellen visual acuity, corrected)
* Current, or alcohol or illicit substance abuse/dependence in the last 3 months
* Contraindications to TMS or MRI: metallic foreign objects, e.g., aneurysm clips/pacemakers, or questionable history of metal fragments, claustrophobia
* Women who are pregnant or breastfeeding. All women participants of reproductive age are required to have a negative pregnancy test prior to enrollment and use medically acceptable birth control throughout the study (barrier and/or oral contraceptives)
* Current psychotic symptoms
* An increased risk of seizure, determined by history
* Medications judged to notably affect cortical excitability e.g., anticonvulsants or high-dose benzodiazepines (\> 4 mg/day of clonazepam or equivalent)
* Predominant hoarding symptoms
18 Years
70 Years
ALL
Yes
Sponsors
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University of Rochester
OTHER
Harvard University
OTHER
University of Pittsburgh
OTHER
University of Puerto Rico
OTHER
Butler Hospital
OTHER
Responsible Party
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Locations
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Butler Hospital
Providence, Rhode Island, United States
Countries
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Related Links
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Related Info
Other Identifiers
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